Çocukluk çağı tromboz olgularında faktör V 1691 G-A değişiminin tromboz oluşumuna yaş değişiminin etkisinin araştırılması
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Date
2009
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Biyoteknoloji Enstitüsü
Abstract
Human coagulation factor V (FV) is an essential coagulation protein with functions in both the pro - and anticoagulant pathways. Failure to express and control FV functions can either lead to bleeding, or to thromboembolic disease. The most common inherited risk factor for thrombosis is a single point mutation in the blood coagulation factor V gene (G1691A), which results in phenotype called APC Resistance. The mutation, which occurs at one of the APC cleavage sites factor V, is located at nucleotide position 1691 and substitutes a G for an A, correspending to the replacement of arginine with glutamine at codon 506. The mutant factor V is known as ?Factor V R506Q? or ?Factor V Leiden (FVL)? and FVL has full procoagulant capacity.In this study, we studied correlation between FVL 1691 G > A mutation and age alterations in pediatric thrombosis. We found the risky age groups for thrombosis in pediatric thrombosis. Two groups of children were selected, i.e with thrombus attack (n=372) and age matched non-thrombotic group (n=336).We used the Kaplan ? Meier statistical method for statistical analysis. We compare two groups for Factor V Leiden mutation. We found that, 1691 G > A mutation in factor V gene is effective on thrombosis.
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Faktör V, Tromboz olguları