Comparıson of toxıc and antıtoxıc effects of cısplatın and camp, at cyp1a1 gene expressıon level of wıstar albıno type rat lıver

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dc.contributor.authorAras, Emine Sümer
dc.contributor.departmentBiyolojitr_TR
dc.contributor.facultyFen Fakültesitr_TR
dc.date.accessioned2021-11-30T12:18:48Z
dc.date.available2021-11-30T12:18:48Z
dc.date.issued2019
dc.description.abstractThroughout the course of cancer treatment, cisplatin has proven to be a successful chemotherapy agent. Several researches have been conducted in vivo and/or in vitro on gene expression changes occurring with the impact of this agent. The current study focuses on the alterations in CYP1A1 gene expression levels in liver cells by cisplatin and cAMP treatment. CYP1A1 gene which the expression levels were analyzed, encodes a member of the cytochrome P450 superfamily of enzymes. Throughout the study, liver tissues from Wistar-type albino rat, also known as the laboratory rat, were used. For normalization of the data, the housekeeping gene TATA box binding protein (TBP) was preferred. The results showed that; gene expression was reduced in tissues subjected independently to cisplatin and cAMP, however the tissues treated with cAMP showed further reduction in gene expression levels. In contrast, tissues subjected to both cisplatin and cAMP showed an increase in the level of expression. This study aims to provide an alternative perspective for comparative toxicology cases and will also serve as a guide for elucidation of cases connected with forensic toxicology.tr_TR
dc.description.indexYoktr_TR
dc.identifier.issue1tr_TR
dc.identifier.urihttp://hdl.handle.net/20.500.12575/76527
dc.identifier.volume28tr_TR
dc.language.isoentr_TR
dc.publisherAnkara Üniversitesi Fen Fakültesitr_TR
dc.relation.journalCommunications, Series C: Biologytr_TR
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıtr_TR
dc.subjectcisplatintr_TR
dc.subjectcAMPtr_TR
dc.subjectWistar albinotr_TR
dc.subjectcytochrome p450tr_TR
dc.subjectgene expressiontr_TR
dc.titleComparıson of toxıc and antıtoxıc effects of cısplatın and camp, at cyp1a1 gene expressıon level of wıstar albıno type rat lıvertr_TR
dc.typeArticletr_TR

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Cilt:28 Sayı:01 (2019)