Browsing by Author "Uysalel, Asuman"

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    Genel anestezi ile sezeryanda indüksiyon amaçlı kullanılan tiyopental ve propofolün anne ve fetusda lipid peroksidasyonu üzerine etkisi
    (Tıp Fakültesi, 2007) Serdaroğlu, Hacer; Uysalel, Asuman; Anesteziyoloji ve Reanimasyon
    In this study, we planned the compare the effects on oxidative stress of a well known antioxidant agent propofol and thiopental whose effects on oxidative stress is not well known by using them as general anesthesia induction agents .40 patients who underwent caesarian section under general anesthesia enrolled to the study. There were 19 patients in propofol group and 21 patients in thiopental group. General anesthesia in both groups maintained with sevoflurane. Intraoperative hemodynamic data, peripheral oxygen saturations, anesthesia, surgery and baby delivery times were recorded. Blood samples were collected at the baseline and at baby delivery from mother and also fetal cord sample was collected from baby. MDA, MPO, Nox, nitrite as oxidative stress marker and SOD as a marker of antioxidant capacity were studied. At baby delivery fetal venous blood gas sample from fetal cord and arterial blood gas sample from mother was collected.There were no statistically significant differences between groups in demographic data, hemodynamic data, peripheral oxygen saturations, and, anesthesia, surgery and baby deliver times and 1. and 5. minute apgar score. Hemodynamic data and peripheral oxygen saturations in groups at different times showed statistically significant differences but these were not considered as clinically important.In thiopenthal group MPO levels were decreased after induction compared to basal levels. There were no statistically significant differences in baseline values between groups but after the induction there were increase in SOD values in thiopenthal group. In baby cord blood samples, NOx and nitrite levels were statistically significant lower in propofol group. Only base excess were statistically significant lower in propofol group in baby delivery mother arterial blood gase evaulation. Only oxygen saturation is statistically significant lower in propofol group compared to other group in cord blood gas evaluation there were no statistically significant difference in other parameters.In conclusion, according to the results of this study, which is a member of limited studies evaluating the effects of anesthetic method on oxidative stress in caesarian section, induction with propofol and thiopental in caeserian section have similar effects and none of them is better than the other in view of oxidative stress.
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    Jinekolojik cerrahi geçiren hastalarda intravenöz midazolam ile bilinçli sedasyonun amnezik etkilerinin bispektral indeks monitorizasyonu, resim hatırlama testi ve sözel bilgi hatırlama testi ile değerlendirilmesi
    (Sağlık Bilimleri Enstitüsü, 2011) Köksoy, Ülkü Ceren; Uysalel, Asuman; Anesteziyoloji ve Reanimasyon
    The evaluation of the amnesic effects of midazolam used for conscious sedation via bispectral index monitorization, picture recall test and verbal information recall test in patients undergoing gynecologic surgeryIn this study we aimed to evaluate the amnesic effects of midazolam used for conscious sedation via bispectral index monitorization (BIS), picture recall test and verbal information recall test in patients undergoing gynecologic surgery.One hundred and sixty patients, aging between 18-77, classed ASA I-II undergoing gynecologic surgery were included in this study. All the patients received IM 0.5 mg atropine and 50 mg meperidine 15 minutes before entering the operating room (O.R.). After entering the O.R. the patients were monitorised for electrocardiogram (ECG), systolic, diastolic and mean blood pressure (SBP, DBP, MBP), heart rate (HR) and periferic O? saturation (SpO?). Depth of anesthesia was monitorized with BIS. The patients were given % 0.9 saline solution via an 18G (gauge) catheter placed at the back of their hands. The patients ECG, SBP, DBP, MBP, HR and SpO? values are measured 3 minutes before, during and 3 minutes after the application of midazolam.To monitorize the depth of anesthesia BIS monitorization and the Observer?s Assessment of Anesthesia/Sedation (OAA/S) scale were used. The BIS and OAA/S scores were recorded 3 minutes before, during and at the 1., 2. and 3. minutes after the application of midazolam and during anesthesia induction. The patients were informed about the basics of the study.Four pictures were used in this study. All patients were shown one picture before and after midazolam. The patients were told the number of the O.R. they were going to be operated and asked to memorize. Following the application of midazolam the patients were given the words green or blue and were asked to memorize it as well. After the first picture was shown and the first information was given the patients received IV 0.04 mg/kg midazolam. 3 minutes after the application of midazolam the second picture was shown and the second information was told. IV propofol 3 mg/kg was used for anesthesia induction and in the case of endotracheal entubation rocuronium IV 0.6 mg/kg was given. Following the induction IV remifentanyl and fentanyl were used if needed. The BIS monitorization was disconnected after the induction. The day following the surgery the patients were evaluated for their recognition of the pictures and words. The patiens were asked if they had any recall of the preoperative waiting room, their entrance to the O.R., their first conversation with the anesthesiologist, the moment midazolam was given, if used the placement of an urinary catheter and whether there was any pain/discomfort during the procedure and the moment the anesthesia induction started. Their answers were recorded.In 34 patients amnesia occured at the same time midazolam was applied. None of the 9 patients who had an urinary catheter placed had any memory of this incident. Twenty patients could remember the initialization of aneshesia induction postoperatively. While the first picture could be recalled by all the patients, the second picture was recalled by 13 patients. The first word was recalled by 143 and the second was recalled by 9 patients.The patients conscious sedation with midazolam resulted in an increase in HR and decrease in SBP, DBP and MBP. By the means of hemodynamic parameters ASA I and II patients had a statistical significant difference (p<0.05). ASA II patients had higher SBP, DBP, MBP and HR values. ASA I patients had higher SpO? values. ASA II patients had higher mean and median values for age and body weight. ASA I and II patients had no statistically significant difference between them regarding their OAA/S and BIS values (p>0.05). When OAA/S and BIS values were evaluated according to time, for both OAA/S and BIS, the 1., 2. and 3. values recorded were all higher than the 4., 5. and 6. values (p<0.05).The relationship of the BIS 1 value with picture 2, BIS 3 and BIS IND values with word 2 and BIS 1 value with the recall of the application of midazolam were found statistically significant (p<0.05). The relationship of the OAA/S 1, 2, 3 and IND scores with picture 2 and OAA/S 2,3 and IND scores with word 2 were found statistically significant (p<0.05). As we evaluated the correlation between OAA/S and BIS values, only the difference between the OAA/S 1 and BIS 1 values was found statistically significant (p<0.05).The relationship between the recall of picture 2 and word 2 with educational status was found statistically significant (p=0.047, p<0.05; p=0.03, p<0.05 respectively). The recall rates in university graduates were found higher eventhough there was no statistical significance.In our study we saw that conscious sedation with midazolam effects the hemodynamic parameters, provides sufficient amnesia, relieves anxiety and that the amnestic effect could be monitored with BIS monitorization and OAA/S scale. Also we concluded that because it provides a more objective value and easier evaluation, BIS monitorization is far more beneficial for monitoring amnesia.Keywords: Midazolam, amnesia, depth of anesthesia, BIS, OAA/S.