Genel anestezi ile sezeryanda indüksiyon amaçlı kullanılan tiyopental ve propofolün anne ve fetusda lipid peroksidasyonu üzerine etkisi
No Thumbnail Available
Date
2007
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Tıp Fakültesi
Abstract
In this study, we planned the compare the effects on oxidative stress of a well known antioxidant agent propofol and thiopental whose effects on oxidative stress is not well known by using them as general anesthesia induction agents .40 patients who underwent caesarian section under general anesthesia enrolled to the study. There were 19 patients in propofol group and 21 patients in thiopental group. General anesthesia in both groups maintained with sevoflurane. Intraoperative hemodynamic data, peripheral oxygen saturations, anesthesia, surgery and baby delivery times were recorded. Blood samples were collected at the baseline and at baby delivery from mother and also fetal cord sample was collected from baby. MDA, MPO, Nox, nitrite as oxidative stress marker and SOD as a marker of antioxidant capacity were studied. At baby delivery fetal venous blood gas sample from fetal cord and arterial blood gas sample from mother was collected.There were no statistically significant differences between groups in demographic data, hemodynamic data, peripheral oxygen saturations, and, anesthesia, surgery and baby deliver times and 1. and 5. minute apgar score. Hemodynamic data and peripheral oxygen saturations in groups at different times showed statistically significant differences but these were not considered as clinically important.In thiopenthal group MPO levels were decreased after induction compared to basal levels. There were no statistically significant differences in baseline values between groups but after the induction there were increase in SOD values in thiopenthal group. In baby cord blood samples, NOx and nitrite levels were statistically significant lower in propofol group. Only base excess were statistically significant lower in propofol group in baby delivery mother arterial blood gase evaulation. Only oxygen saturation is statistically significant lower in propofol group compared to other group in cord blood gas evaluation there were no statistically significant difference in other parameters.In conclusion, according to the results of this study, which is a member of limited studies evaluating the effects of anesthetic method on oxidative stress in caesarian section, induction with propofol and thiopental in caeserian section have similar effects and none of them is better than the other in view of oxidative stress.
Description
Keywords
Sezeryan, oksidatif stres, antioksidan kapasite, propofol, tiyopental, Caesarian section, oxidative stress, antioxidan capasite, propofol, thiopental