Does Defective Apoptosis Play A Role in Cystic Fibrosis Lung Disease?

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dc.contributor.authorÇobanoğlu, Nazan
dc.contributor.authorIDhttp://orcid.org/0000-0002-3686-2927tr_TR
dc.contributor.departmentTıp Fakültesitr_TR
dc.contributor.otherYalçın, Ebru Güneş
dc.contributor.otherTalim, Beril
dc.contributor.otherÖzçelik, Ugur
dc.contributor.otherDogru, Deniz
dc.contributor.otherPekcan, Sevgi
dc.contributor.otherKiper, Nural
dc.date.accessioned2020-03-27T06:43:36Z
dc.date.available2020-03-27T06:43:36Z
dc.date.issued2009
dc.description.abstractBackground and Aims: Although apoptotic dysfunction has recently been suggested in cystic fibrosis (CF), there are few studies reported concerning apoptosis in CF with controversial results. The aim of this study was to investigate apoptosis in CF human lung tissues and compare with non-CF bronchiectatic and normal healthy lung tissues. We also investigated the relation between apoptosis and histopathological features of tissues and microbiological factors influencing apoptosis. Methods: Lung tissue samples from CF (n = 30), non-CF bronchiectasis (n = 28, BE group) and normal control cases (n = 24, C group) were included in the study. Histological examination of H & E-stained archived slides was performed and TUNEL method was used to detect DNA fragmentation. Results: Apoptotic alveolar epithelial cells were significantly increased in the CF group compared to BE and C groups (p = 0.046). Bronchopneumonia (BP) was present in 15 CF cases (50%), whereas none of the cases in C group had BP (p = 0.0001). Apoptosis was significantly increased in cases with BP (n = 17) compared to cases without BP (n = 65) (p = 0.04). Conclusions: Apoptotic epithelial cells and BP were significantly increased in the CF group and excess level of apoptosis may be the result of enhanced occurrence of BP. Apoptotic cells were alveolar epithelial cells in the great majority of the patients and were not detected in other locations where CFTR expression is much more prominent than alveolar cells. We may postulate that increased apoptotic findings in the alveolar epithelium were related with the presence of chronic infections rather than CFTR dysfunction. © 2009 IMSS.tr_TR
dc.identifier.endpage564tr_TR
dc.identifier.issue7tr_TR
dc.identifier.startpage561tr_TR
dc.identifier.uri-https://doi.org/10.1016/j.arcmed.2009.07.005tr_TR
dc.identifier.urihttp://hdl.handle.net/20.500.12575/70766
dc.identifier.volume40tr_TR
dc.language.isoentr_TR
dc.relation.isversionof10.1016/j.arcmed.2009.07.005tr_TR
dc.relation.journalArchives of Medical Researchtr_TR
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıtr_TR
dc.subjectApoptosistr_TR
dc.subjectLungtr_TR
dc.subjectCystic fibrosistr_TR
dc.titleDoes Defective Apoptosis Play A Role in Cystic Fibrosis Lung Disease?tr_TR
dc.typeArticletr_TR

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