Role of ZIP14 (SLC39A14) gene histidine rich regions in neural tube defects

Simple item page
dc.contributor.authorYılmaz, Erkan
dc.contributor.departmentBiyoteknoloji Enstitüsütr_TR
dc.contributor.otherTorun, Didem
dc.contributor.otherAkar, Ece
dc.contributor.otherAkar, Nejat
dc.date.accessioned2020-05-08T12:29:58Z
dc.date.available2020-05-08T12:29:58Z
dc.date.issued2011
dc.description.abstractNeural tube defects (NTDs) comprise a group of congenital malformations that includes spina bifida, anencephaly, meningomyelocele and encephalocele. Reports have implicated zinc deficiency as one of the causative factors of NTDs. Both environmental and genetic factors are involved in the etiology of NTDs. Inadequate folate intake and nutritional deficiency are important environmental risk factors. The aim of this study was to determine the relation of a zinc related gene ZRT and IRT like protein 14 (ZIP14) and neural tube defects in Turkish patients. The case control study included seventy Turkish mothers who gave birth to NTD infants. Two hundred and thirty-nine healthy controls were consecutively selected without any congenital defects or familial NTD history. Following DNA extraction, PCR, SSCP and DNA sequencing analysis of exons of the ZIP14 gene were performed. Our data revealed that no relation of neural tube defects and ZIP14 was detected in Turkish NTD patients. Zinc deficiency have been reported as a risk factor for Turkish population and other possible zinc related gene defects may have importancetr_TR
dc.identifier.endpage137tr_TR
dc.identifier.issue2tr_TR
dc.identifier.startpage135tr_TR
dc.identifier.urihttps://doi.org/10.1016/j.ejmhg.2011.06.006tr_TR
dc.identifier.urihttp://hdl.handle.net/20.500.12575/71231
dc.identifier.volume12tr_TR
dc.language.isoentr_TR
dc.relation.isversionof10.1016/j.ejmhg.2011.06.006tr_TR
dc.relation.journalEgyptian Journal of Medical Human Geneticstr_TR
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıtr_TR
dc.subjectNeural tube defects (NTDs)tr_TR
dc.subjectZinctr_TR
dc.subjectZIP14tr_TR
dc.titleRole of ZIP14 (SLC39A14) gene histidine rich regions in neural tube defectstr_TR
dc.typeArticletr_TR

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
Green_EY_Role of ZIP14 (SLC39A14) gene histidine rich regions in neural tube defects.pdf
Size:
492.6 KB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.62 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

Makale