Evaluation of rat kidney aldose reductase inhibitory activity of some N-acetyl dehydroalanine derivatives

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dc.contributor.authorSüzen, Sibel
dc.contributor.departmentEczacılık Fakültesitr_TR
dc.contributor.otherDaş Evci̇Men, Net
dc.contributor.otherSarikaya, Mutlu
dc.contributor.otherGürkök, Gökce
dc.date.accessioned2020-03-18T08:09:00Z
dc.date.available2020-03-18T08:09:00Z
dc.date.issued2011
dc.description.abstractAldose reductase (AR) is an enzyme that catalyzes the conversion of glucose to sorbitol, which is in turn converted to fructose by sorbitol dehydrogenase. Increased AR activity has been implicated in the pathogenesis of diabetic complications such as neuropathy, nephropathy, retinopathy, and cataract. Inhibitors of AR thus seem to have the potential to prevent or treat diabetic complications. At present, however, side effects and/or insufficient pharmacokinetic profiles have made most of the drug candidates undesirable. In this study, the synthesis (l-o) and ARI activity of 15 N-acetyl dehydroalanine derivatives (a-o) are described. The synthesized compounds mainly contained aliphatic and aromatic side chains. The insertion of ethyl and chloro propyl side chains were shown to be more effective than the rest of the compounds. Between the synthesized compounds N-ethyl (b) and N-propylchloride (h) derivatives showed the best ARI activities. © 2011 Springer Science+Business Media, LLC.tr_TR
dc.description.indexScopus
dc.identifier.endpage460tr_TR
dc.identifier.issue4tr_TR
dc.identifier.startpage453tr_TR
dc.identifier.urihttps://doi.org/10.1007/s00044-010-9337-ytr_TR
dc.identifier.urihttp://hdl.handle.net/20.500.12575/70725
dc.identifier.volume20tr_TR
dc.language.isoentr_TR
dc.relation.isversionof10.1007/s00044-010-9337-ytr_TR
dc.relation.journalMedicinal Chemistry Researchtr_TR
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıtr_TR
dc.subjectAldose reductasetr_TR
dc.subjectDehydroalaninetr_TR
dc.subjectInhibitiontr_TR
dc.subjectPolyol pathwaytr_TR
dc.subjectSynthesistr_TR
dc.titleEvaluation of rat kidney aldose reductase inhibitory activity of some N-acetyl dehydroalanine derivativestr_TR
dc.typeArticletr_TR

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