Behaviour of 9-Ethyl-9H-carbazole Hydrazone Derivatives Against Oxidant Systems: Protective Effect on Amyloid β-Induced Damage

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dc.contributor.authorSüzen, Sibel
dc.contributor.departmentEczacılık Fakültesitr_TR
dc.contributor.otherGurer, Hande
dc.contributor.otherKaraaslan, Cigdem
dc.contributor.otherInce,Elif
dc.contributor.otherTavakkoli, Mercan
dc.contributor.otherLuciano, Saso
dc.contributor.otherFiruzi,Omidreza
dc.date.accessioned2020-03-17T13:35:31Z
dc.date.available2020-03-17T13:35:31Z
dc.date.issued2019
dc.description.abstractAntioxidants are helpful in prevention of several diseases related with oxidative stress including neurodegenerative disorders. In recent studies, carbazoles were given proof of promising antioxidant activities. In this article, 9-ethyl-9H-carbazole hydrazone derivatives were synthesized, characterized and their in vitro antioxidant activity and possible cytotoxic effects were investigated. Furthermore, protective effect of the synthesized derivatives against amyloid β-induced damage in PC12 neuronal cells was examined by using MTT assay. The newly synthesized carbazoles were found to have radical scavenging activity with a varying potency both in cell-free and cell-based in vitro assays. Several compounds, especially such as 3d and 3e, 3m and 3n bearing two halogen groups on the phenyl ring, were found to have cytotoxic activity. However, their cytotoxic activities were not higher than that of melatonin. Several compounds also significantly protected neuronal PC12 cells against amyloid β-induced damage, which can be defined as neuroprotective agents. (4-(2-((9-Ethyl-9H-carbazol-3-yl)methylene)hydrazinyl)benzonitrile) 3r was found as the most active compound with both radical scavenging activity and neuroprotective effects against amyloid β-induced damage. These findings might provide an alternative strategy for developing novel carbazole derivatives for management of neurodegenerative diseases, such as Alzheimer's disease.tr_TR
dc.identifier.endpage8tr_TR
dc.identifier.issn/e-issn0011-1643
dc.identifier.issue1tr_TR
dc.identifier.startpage1tr_TR
dc.identifier.urihttps://doi.org/10.5562/cca3481tr_TR
dc.identifier.urihttp://hdl.handle.net/20.500.12575/70707
dc.identifier.volume92tr_TR
dc.language.isoentr_TR
dc.relation.isversionof10.5562/cca3481tr_TR
dc.relation.journalCroat. Chem. Actatr_TR
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıtr_TR
dc.subjectcarbazole,tr_TR
dc.subjectantioxidant,tr_TR
dc.subjectcytotoxicity,tr_TR
dc.subjectalzheimer’s disease,tr_TR
dc.subjectβ-amyloid.tr_TR
dc.titleBehaviour of 9-Ethyl-9H-carbazole Hydrazone Derivatives Against Oxidant Systems: Protective Effect on Amyloid β-Induced Damagetr_TR
dc.typeArticletr_TR

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