Propofol Versus Thiopental for Rapid-Sequence Induction in Isolated Systolic Hypertensive Patients: A Factorial Randomized Double-Blind Clinical Trial
| dc.contributor.author | Ali Abbas, Yılmaz | |
| dc.contributor.department | Tıp Fakültesi | tr_TR |
| dc.date.accessioned | 2020-12-04T09:06:14Z | |
| dc.date.available | 2020-12-04T09:06:14Z | |
| dc.date.issued | 2018 | |
| dc.description.abstract | Objective: We investigated the effects of four different anaesthesia induction protocols on the haemodynamic response to laryngoscopy and tracheal intubation during rapid-sequence induction (RSI) in systolic hypertensive patients. Methods: One hundred and twenty hypertensive adult patients (systolic pressure >140 mmHg and diastolic pressure <90 mmHg), classified according to the American Association of Anesthesiologists as Class II and III were randomized into four groups. After pre-oxygenation for 3 minutes, induction and tracheal intubation were performed by blinded investigators, who also scored the intubation. Study groups composed of 30 patients each received lidocaine 1 mg kg-1+thiopental 5 mg kg-1 or remifentanil 1 μg kg-1+thiopental 5 mg kg-1 or lidocaine 1 mg kg-1+propofol 2 mg kg-1 or remifentanil 1 μg kg-1+propofol 2 mg kg-1. Succinylcholine was the muscle relaxant. Haemodynamic data were obtained before (baseline) and after induction, at intubation, and at 1, 3, 5 and 10 minutes after intubation. A rise or drop in the arterial blood pressure and heart rate >20% were considered to be significant. Results: Patients receiving remifentanil+propofol had a reduction in the systolic and mean blood pressure >20% when compared to patients receiving remifentanil and thiopental: systolic values were 125±27 mmHg in the remifentanil+propofol group versus 153±35 mmHg in the remifentanil+thiopental group 1 minute after intubation (p<0.01); the mean arterial pressure values were 87±18 mmHg in the remifentanil+propofol group versus 105±25 mmHg in the remifentanil+thiopental group 1 minute after intubation (p<0.05). Conclusion: Propofol was not superior to thiopental for the attenuation of the response to laryngoscopy and intubation during RSI in systolic hypertensive patients, whereas propofol+remifentanil combination appears to be so in terms of the heart rate stability. | tr_TR |
| dc.description.index | Pubmed | |
| dc.identifier.uri | https://doi.org/10.5152/TJAR.2018.44442 | tr_TR |
| dc.identifier.uri | http://hdl.handle.net/20.500.12575/72552 | |
| dc.language.iso | en | tr_TR |
| dc.relation.isversionof | 10.5152/TJAR.2018.44442 | tr_TR |
| dc.relation.journal | Turk J Anaesthesiol Reanim . | tr_TR |
| dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | tr_TR |
| dc.subject | Rapid sequence induction | tr_TR |
| dc.subject | isolated systolic hypertension | tr_TR |
| dc.subject | propofol | tr_TR |
| dc.subject | remifentanil | tr_TR |
| dc.title | Propofol Versus Thiopental for Rapid-Sequence Induction in Isolated Systolic Hypertensive Patients: A Factorial Randomized Double-Blind Clinical Trial | tr_TR |
| dc.type | Article | tr_TR |