Prognostic factors for stage I lung adenocarcinoma and surgical management of subsolid nodules

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dc.contributor.authorKocaman, Gökhan
dc.contributor.departmentTıp Fakültesitr_TR
dc.date.accessioned2020-12-04T09:02:25Z
dc.date.available2020-12-04T09:02:25Z
dc.date.issued2018
dc.description.abstractBackground: This study aims to identify the prognostic factors for stage I lung adenocarcinoma and to evaluate the surgical management of subsolid nodules. Methods: The study included 133 patients (90 males, 43 females; mean age 64.9 years; range, 29 to 82 years) who had undergone operation in our clinic for stage I lung adenocarcinoma between January 2007 and December 2015. Clinical, radiological and pathological data were retrospectively evaluated and their effects on recurrence and survival were examined by Kaplan-Meier and Cox regression analyses. Results: Comparing the histopathological tumor types according to the pathological tumors size, we determined that the prevalence of invasive adenocarcinoma significantly increased with increasing tumor size (p<0.001). For all nodules, a tumor disappearance rate lower than 25% negatively influenced disease-free survival and a maximum standardized uptake value higher than 5.6 negatively influenced overall survival (p=0.027 for both). The grouping, which was performed considering the maximum standardized uptake value 5.6 as the cut-off value, was an independent prognostic factor for overall survival (hazard ratio: 5.973, 95% confidence interval: 1.186-30.073, p=0.03). Five-year overall survival rate was statistically significantly higher in patients who underwent wedge resection or segmentectomy for subsolid nodules compared to those who underwent lobectomy (100% vs. 79.3%, p=0.044). Conclusion: Sublobar resections can be safely performed in subsolid nodules smaller than 2 cm in diameter with tumor disappearance rate ≥25% and maximum standardized uptake value ≤5.6.tr_TR
dc.description.indexPubmed
dc.identifier.endpage620tr_TR
dc.identifier.issue4tr_TR
dc.identifier.startpage614tr_TR
dc.identifier.urihttps://doi.org/10.5606/tgkdc.dergisi.2018.15846tr_TR
dc.identifier.urihttp://hdl.handle.net/20.500.12575/72525
dc.identifier.volume26tr_TR
dc.language.isoentr_TR
dc.relation.isversionof10.5606/tgkdc.dergisi.2018.15846tr_TR
dc.relation.journalTurk Gogus Kalp Damar Cerrahisi Derg .tr_TR
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıtr_TR
dc.subjectAdenocarcinomatr_TR
dc.subjectstage Itr_TR
dc.subjectsubsolid nodulestr_TR
dc.titlePrognostic factors for stage I lung adenocarcinoma and surgical management of subsolid nodulestr_TR
dc.typeArticletr_TR

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