Plasma amino-terminal propeptide of C-type natriuretic peptide concentration in normal-weight and obese children
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Date
2017
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Abstract
Objective: In studies on the relationship between amino-terminal propeptide of C-type natriuretic peptide (NT-proCNP) concentration
and height velocity in children, CNP has been implicated as an emerging new growth marker during childhood. It has been reported
that besides its well-studied role in growth, plasma CNP levels are reduced in overweight and/or obese adolescents, suggesting CNP as a
potential biomarker in childhood obesity. The primary goal of this study was to test this hypothesis in a Turkish population.
Methods: Consent was taken from 317 children [ages 0-18 (158 girls, 159 boys)] and their parents. All subjects were physically examined;
anthropometric measurements were obtained. Body mass index was calculated. During routine blood work, 1 mL extra blood was taken.
Plasma NT-proCNP concentration was measured by enzyme-linked immunosorbent assay.
Results: Results confirmed the previously described relationship between plasma NT-proCNP concentration and growth velocity. Plasma
NT-proCNP concentration showed a negative correlation with age, weight, and height in children. Gender was not a factor that alters the
age-dependent plasma NT-proCNP concentration until puberty.
Conclusion: Unlike previous reports, plasma NT-proCNP concentration of overweight/obese children was not significantly lower than
that of children with normal weight in age groups analyzed in a Turkish population. Thus, it is too early to conclude that CNP is a potential
biomarker in childhood obesity. Further studies are necessary to address this question.
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Keywords
C-type natriuretic peptide, Amino-terminal propeptide of C-type natriuretic peptide, Obesity, Overweight, Growth, Biomarker