Association of simple hematological parameters with disease manifestations, activity, and severity in patients with systemic sclerosis

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dc.contributor.authorKınıklı, Gülay
dc.contributor.departmentTıp Fakültesitr_TR
dc.contributor.otherYayla, Müçteba Enes
dc.contributor.otherOkatan, İlyas Ercan
dc.contributor.otherYurteri, Emine uslu
dc.contributor.otherDinçer, Ayşe Bahar Keleşoğlu
dc.contributor.otherTorğutalp, Murat
dc.contributor.otherGülöksüz, Emine Gözde Aydemir
dc.contributor.otherSezer, Serdar
dc.contributor.otherTurgay, Tahsin Murat
dc.contributor.otherAteş, Aşkın
dc.date.accessioned2020-03-13T12:27:44Z
dc.date.available2020-03-13T12:27:44Z
dc.date.issued2020
dc.description.abstractIntroduction/objectives Neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), mean platelet volume (MPV),andredcelldistributionwidth(RDW)maypotentiallyreflectinflammatorystatusinsystemicautoimmunediseases.The aim of this study is to investigate the association between these proposed markers and disease manifestations, activity, and severity in systemic sclerosis (SSc). Method We conducted a cross-sectional study of 69 systemic sclerosis (SSc) patients and 50 healthy volunteers in a single center. Adult patients with SSc and healthy controls were compared in terms of NLR, MLR, MPV, RDW, erythrocyte sedimentation rate (ESR),andC-reactiveprotein(CRP).Venousbloodsamplesweredrawnafteratleast8hoffastinginthemorning.Extensionofskin fibrosiswasevaluatedbyusingmodifiedRodnanskinscore(mRSS).DiseaseseverityandactivitywereassessedbyMedsgerdisease severityandEuropeanSclerodermaTrialsandResearchGroup(EUSTAR)diseaseactivityscores,respectively.Associationsofdisease manifestations,clinical,laboratory,andcapillaroscopicfindings,mRSS,andthediseaseactivityandseverityscoreswiththeproposed hematological markers were evaluated. Multiple regression models were generated for significant associations. Results Theneutrophilnumberwashigher(p=0.004)andlymphocytenumberwaslower(p<0.001)inSScgroupcomparedto controls. SSc group also had higher NLR, MLR, and RDW. In multiple logistic regression, only the NLR (regression coefficient=3.49, p=0.031) and CRP (regression coefficient=0.17, p=0.037) remained significantly different between SSc and healthy control groups (Cox and SnellR2 =0.243,NagelkerkeR2 =0.337,p<0.001). NLR and MLR positively correlated with mRSS, EUSTAR score, and CRP. MLR also positively correlated with Medsger score. Higher monocyte counts independently predicted higher EUSTAR and Medsger scores in multiple linear regressions. Patients with digital ulcers had higher NLR and MLR. We did not find any difference in MPV values between SSc and healthy control groups. Conclusions Globally available and inexpensive hematological tests, particularly the NLR and MLR, may be associated with vascular and cutaneous manifestations as well as disease activity and severity in SSc.tr_TR
dc.description.indexScopus
dc.description.indexPubmed
dc.identifier.endpage83tr_TR
dc.identifier.issn/e-issn0770-3198
dc.identifier.issn/e-issn1434-9949
dc.identifier.startpage77tr_TR
dc.identifier.urihttps://doi.org/10.1007/s10067-019-04685-0tr_TR
dc.identifier.urihttp://hdl.handle.net/20.500.12575/70424
dc.identifier.volume39tr_TR
dc.language.isoentr_TR
dc.publisherSpringer Naturetr_TR
dc.relation.isversionof10.1007/s10067-019-04685-0tr_TR
dc.relation.journalClinical Rheumatologytr_TR
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıtr_TR
dc.subjectComplete blood counttr_TR
dc.subjectMLRtr_TR
dc.subjectMonocyte-to-lymphocyte ratiotr_TR
dc.subjectNeutrophil-to-lymphocyte ratiotr_TR
dc.subjectNLRtr_TR
dc.subjectSclerodermatr_TR
dc.subjectSystemic sclerosistr_TR
dc.titleAssociation of simple hematological parameters with disease manifestations, activity, and severity in patients with systemic sclerosistr_TR
dc.typeArticletr_TR

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