Interferon-alpha-2a and zinc combination therapy in cildren with chronic hepatitis B infection.
dc.contributor.author | Kansu Tanca, Aydan | |
dc.contributor.department | Tıp Fakültesi | tr_TR |
dc.contributor.other | Kuloğlu, Z | |
dc.date.accessioned | 2020-04-02T11:44:45Z | |
dc.date.available | 2020-04-02T11:44:45Z | |
dc.date.issued | 2011-12 | |
dc.description.abstract | Zinc has been reported to enhance the response to interferon (IFN) or PEG-IFN plus ribavirin therapy, improve liver function, and ameliorate hematologic side effects in patients with chronic hepatitis C. However, the role of zinc supplementation during IFN therapy in chronic hepatitis B infection (CHB) remains unclear. We therefore aimed to report the results of zinc and IFN-alpha-2a therapy in children with CHB. Twenty-two naive, HBeAg-positive children (mean age 10.4±4.4 years) received IFN-!2a (9 MU/m2 sc) for 6 months plus peroral zinc (7.5 mg/day for <10 years and 10 mg/day for >10 years) for 12 months. Serum zinc, alanine aminotransferase (ALT), complete blood count, hepatitis B virus DNA (HBV DNA), and serological markers were measured. Histological (HR) and sustained response (SR) were evaluated at 6 months after completion of therapy. Normalization of ALT, HBeAg seroconversion, and HBV DNA<10,000 copies/ml were considered as SR. HR was defined as decrease in Knodell histological activity index (HAI) score by at least 2 points compared to baseline. End of therapy ALT level and log HBV DNA were significantly lower than pretherapy levels (p=0.001 and p=0.001, respectively), while zinc level was not different. Portal inflammation score significantly decreased after therapy (p=0.043), however, total HAI and other HAI components were not different. SR and HR were 25% and 52.9%. In conclusion as a first study investigating the effect of zinc and IFN combination therapy in children with CHB, SR and HR rates were not better than previously reported monotherapy or combination therapies. | tr_TR |
dc.identifier.endpage | 1309 | tr_TR |
dc.identifier.issue | 3 | tr_TR |
dc.identifier.startpage | 1302 | tr_TR |
dc.identifier.uri | https://doi.org/10.1007/s12011-011-8971-7. | tr_TR |
dc.identifier.uri | http://hdl.handle.net/20.500.12575/70887 | |
dc.identifier.volume | 143 | tr_TR |
dc.language.iso | en | tr_TR |
dc.relation.isversionof | 10.1007/s12011-011-8971-7. | tr_TR |
dc.relation.journal | Biol Trace Elem Res | tr_TR |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | tr_TR |
dc.subject | Children . Chronic Hepatitis B infection . Interferon . Zin | tr_TR |
dc.title | Interferon-alpha-2a and zinc combination therapy in cildren with chronic hepatitis B infection. | tr_TR |
dc.type | Article | tr_TR |
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