Interferon-alpha-2a and zinc combination therapy in cildren with chronic hepatitis B infection.

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dc.contributor.authorKansu Tanca, Aydan
dc.contributor.departmentTıp Fakültesitr_TR
dc.contributor.otherKuloğlu, Z
dc.date.accessioned2020-04-02T11:44:45Z
dc.date.available2020-04-02T11:44:45Z
dc.date.issued2011-12
dc.description.abstractZinc has been reported to enhance the response to interferon (IFN) or PEG-IFN plus ribavirin therapy, improve liver function, and ameliorate hematologic side effects in patients with chronic hepatitis C. However, the role of zinc supplementation during IFN therapy in chronic hepatitis B infection (CHB) remains unclear. We therefore aimed to report the results of zinc and IFN-alpha-2a therapy in children with CHB. Twenty-two naive, HBeAg-positive children (mean age 10.4±4.4 years) received IFN-!2a (9 MU/m2 sc) for 6 months plus peroral zinc (7.5 mg/day for <10 years and 10 mg/day for >10 years) for 12 months. Serum zinc, alanine aminotransferase (ALT), complete blood count, hepatitis B virus DNA (HBV DNA), and serological markers were measured. Histological (HR) and sustained response (SR) were evaluated at 6 months after completion of therapy. Normalization of ALT, HBeAg seroconversion, and HBV DNA<10,000 copies/ml were considered as SR. HR was defined as decrease in Knodell histological activity index (HAI) score by at least 2 points compared to baseline. End of therapy ALT level and log HBV DNA were significantly lower than pretherapy levels (p=0.001 and p=0.001, respectively), while zinc level was not different. Portal inflammation score significantly decreased after therapy (p=0.043), however, total HAI and other HAI components were not different. SR and HR were 25% and 52.9%. In conclusion as a first study investigating the effect of zinc and IFN combination therapy in children with CHB, SR and HR rates were not better than previously reported monotherapy or combination therapies.tr_TR
dc.identifier.endpage1309tr_TR
dc.identifier.issue3tr_TR
dc.identifier.startpage1302tr_TR
dc.identifier.urihttps://doi.org/10.1007/s12011-011-8971-7.tr_TR
dc.identifier.urihttp://hdl.handle.net/20.500.12575/70887
dc.identifier.volume143tr_TR
dc.language.isoentr_TR
dc.relation.isversionof10.1007/s12011-011-8971-7.tr_TR
dc.relation.journalBiol Trace Elem Restr_TR
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıtr_TR
dc.subjectChildren . Chronic Hepatitis B infection . Interferon . Zintr_TR
dc.titleInterferon-alpha-2a and zinc combination therapy in cildren with chronic hepatitis B infection.tr_TR
dc.typeArticletr_TR

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