Novel indole-based analogs of melatonin: synthesis and in vitro antioxidant activity studies

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dc.contributor.authorSüzen, Sibel
dc.contributor.authorSeçkin, Özden
dc.contributor.authorShirinzadeh, Hanif
dc.contributor.departmentEczacılık Fakültesitr_TR
dc.date.accessioned2019-06-27T13:32:00Z
dc.date.available2019-06-27T13:32:00Z
dc.date.issued2010
dc.description.abstractThe aim of this study was to synthesize and examine possible in vitro antioxidant effects of indole-based melatonin analogue compounds. As a part of our ongoing study nineteen indole hydrazide/hydrazone derivatives were synthesized, characterized and their in vitro antioxidant activity was investigated by three different assays: by evaluating their reducing effect against oxidation of a redox sensitive fluorescent probe, by examining their protective effect against H(2)O(2)-induced membrane lipid peroxidation and by determining their inhibitory effect on AAPH-induced hemolysis of human erythrocytes. The results indicated significant strong antioxidant activity for most of the compounds, when compared to melatonin.tr_TR
dc.description.abstractScopus
dc.description.indexWos
dc.identifier.endpage2202tr_TR
dc.identifier.issue04tr_TR
dc.identifier.other10.3390/molecules15042187
dc.identifier.startpage2187tr_TR
dc.identifier.urihttp://hdl.handle.net/20.500.12575/66846
dc.identifier.urihttps://doi.org/10.3390/molecules15042187
dc.identifier.volume15tr_TR
dc.language.isoentr_TR
dc.relation.isversionof10.3390/molecules15042187
dc.relation.journalMoleculestr_TR
dc.subjectIndoletr_TR
dc.subjectHydrazonetr_TR
dc.subjectHydrazidetr_TR
dc.subjectMelatonintr_TR
dc.subjectSynthesistr_TR
dc.subjectAntioxidant activitytr_TR
dc.titleNovel indole-based analogs of melatonin: synthesis and in vitro antioxidant activity studiestr_TR
dc.typeArticletr_TR

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