Sorbicillinoid-Based Metabolites from a Sponge-Derived Fungus Trichoderma saturnisporum

Simple item page
dc.contributor.authorHeydari, Hajar
dc.contributor.departmentEczacılık Fakültesitr_TR
dc.date.accessioned2020-12-21T11:18:37Z
dc.date.available2020-12-21T11:18:37Z
dc.date.issued2018
dc.description.abstractAntibacterial activity assessment and high performance liquid chromatography associated with nuclear magnetic resonance (HPLC/NMR) data revealed that the EtOAc extract of the fermented endophytic fungus Trichoderma saturnisporum DI-IA, obtained from the marine sponge Dictyonella incisa, contained conjugated olefinic metabolites with antibacterial activity. Chemical examination of the fungal strain resulted in the isolation of eight new sorbicillinoid-based compounds, namely saturnispols A⁻H (1⁻8). Their structures were determined on the basis of extensive spectroscopic analysis, including the experimental and calculated electronic circular dichroism (ECD) data for the configurational assignments. Saturnispol F exerted significant inhibition against a panel of bacteria strains including vancomycin-resistant enterococci (VRE) with a minimum inhibitory concentrations (MIC) ranging from 1.63 to 12.9 μg/mL, while saturnispol H showed selective effects against VRE and B. subtilis.tr_TR
dc.description.indexPubmed
dc.description.indexPubmed
dc.identifier.endpage15tr_TR
dc.identifier.issue7tr_TR
dc.identifier.startpage1tr_TR
dc.identifier.urihttps://doi.org/10.3390/md16070226tr_TR
dc.identifier.urihttp://hdl.handle.net/20.500.12575/72573
dc.identifier.volume16tr_TR
dc.language.isoentr_TR
dc.relation.isversionof10.3390/md16070226tr_TR
dc.relation.journalMar Drugs .tr_TR
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıtr_TR
dc.subjectTrichoderma saturnisporumtr_TR
dc.subjectantibacterial effectstr_TR
dc.subjectmarine fungustr_TR
dc.titleSorbicillinoid-Based Metabolites from a Sponge-Derived Fungus Trichoderma saturnisporumtr_TR
dc.typeArticletr_TR

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
marinedrugs-16-00226.pdf
Size:
2.25 MB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.62 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

Makale
PubMed İndeksli Yayınlar