Synthesis and Potent Antimicrobial Activity of Some Novel N-(Alkyl)-2-Phenyl-1H-Benzimidazole-5-Carboxamidines

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dc.contributor.authorGöker, Hakan
dc.contributor.authorAlp, Mehmet
dc.contributor.authorYıldız, Serap Süzük
dc.contributor.departmentEczacılık Fakültesitr_TR
dc.date.accessioned2020-02-15T13:19:38Z
dc.date.available2020-02-15T13:19:38Z
dc.date.issued2005
dc.description.abstractA series of 22 novel 1,2-disubstituted-1H-benzimidazole-N-alkylated-5-carboxamidine derivatives were synthesized and evaluated for in vitro antibacterial activity against S. aureus and methicillin resistant S. aureus (MRSA), E. coli, E. faecalis and for antifungal activity against C. albicans. Compound 59 [1-(2,4-dichlorobenzyl)-N-(2-diethylaminoethyl)-1H-benzimidazole-5-carboxamidine], with a 3,4-dichlorophenyl group at the C-2 position, displayed the greatest activity (MIC = 3.12 μg/mL against both some bacteria and the fungus C. albicans).tr_TR
dc.description.indexScopus
dc.description.indexWos
dc.identifier.endpage1386tr_TR
dc.identifier.issn/e-issn1420-3049
dc.identifier.issue11tr_TR
dc.identifier.startpage1377tr_TR
dc.identifier.urihttps://doi.org/10.3390/10111377tr_TR
dc.identifier.urihttp://hdl.handle.net/20.500.12575/69566
dc.identifier.volume10tr_TR
dc.language.isoentr_TR
dc.relation.isversionof10.3390/10111377tr_TR
dc.relation.journalMoleculestr_TR
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıtr_TR
dc.rightsCC0 1.0 Universal*
dc.rights.urihttp://creativecommons.org/publicdomain/zero/1.0/*
dc.subjectmethicillin-resistant Str_TR
dc.subjectantibacterial activitytr_TR
dc.subjectantifungal activitytr_TR
dc.titleSynthesis and Potent Antimicrobial Activity of Some Novel N-(Alkyl)-2-Phenyl-1H-Benzimidazole-5-Carboxamidinestr_TR
dc.typeArticletr_TR

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