Synthesis and potent antimicrobial activity of some novel N-(Alkyl)-2-phenyl-1H-benzimidazole-5-carboxamidines

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dc.contributor.authorAlp, Mehmet
dc.contributor.authorYıldız, Sulhiye
dc.contributor.authorGöker, Hakan
dc.contributor.departmentEczacılık Fakültesitr_TR
dc.date.accessioned2019-06-27T14:12:45Z
dc.date.available2019-06-27T14:12:45Z
dc.date.issued2005
dc.description.abstractA series of 22 novel 1,2-disubstituted-1H-benzimidazole-N-alkylated-5-carboxamidine derivatives were synthesized and evaluated for in vitro antibacterial activity against S. aureus and methicillin resistant S. aureus (MRSA), E. coli, E. faecalis and for antifungal activity against C. albicans. Compound 59 [1-(2,4-dichlorobenzyl)-N-(2-diethylaminoethyl)-1H-benzimidazole-5-carboxamidine], with a 3,4-dichlorophenyl group at the C-2 position, displayed the greatest activity (MIC = 3.12 mu g/mL against both some bacteria and the fungus C. albicans).tr_TR
dc.description.indexWos
dc.description.indexwos
dc.identifier.endpage1386tr_TR
dc.identifier.issue11tr_TR
dc.identifier.other10.3390/10111377
dc.identifier.startpage1377tr_TR
dc.identifier.urihttp://hdl.handle.net/20.500.12575/66857
dc.identifier.volume10tr_TR
dc.language.isoentr_TR
dc.relation.indexWostr_TR
dc.relation.journalMoleculestr_TR
dc.subject1H-benzimidazole carboxamidinestr_TR
dc.subjectMethicillin-resistant S. aureus (MRSA)tr_TR
dc.subjectAntibacterial activity and antifungal activitytr_TR
dc.titleSynthesis and potent antimicrobial activity of some novel N-(Alkyl)-2-phenyl-1H-benzimidazole-5-carboxamidinestr_TR
dc.typeArticletr_TR

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