Locally administrated single-dose teriparatide affects critical-size rabbit calvarial defects: A histological, histomorphometric and micro-CT study

dc.contributor.authorOcak, Mert
dc.contributor.departmentSağlık Bilimleri Fakültesitr_TR
dc.date.accessioned2020-11-06T06:58:03Z
dc.date.available2020-11-06T06:58:03Z
dc.date.issued2019
dc.description.abstractObjective: The aim of this study was to evaluate the effect of teriparatide (PTH 1-34, rhPTH) on a rabbit defect model with local xenogen grafts histomorphometrically and radiologically. Methods: For this purpose, two 10 mm diameter critical-size defects were created in the calvaria of 16 rabbits. In the control group, the defect area was filled with a xenogen graft, while in the teriparatide group (PTH 1-34), a xenogen graft combination with 20 mcg teriparatide was used. For both 4 - week and 8 - week study groups, new bone, residual graft, and soft tissue areas were evaluated as well as bone volume histomorphometrically and radiologically. Results: Histomorphometrically, there was a significant difference in new bone area values at the 8th week (p < 0.05), but there was no significant difference between the 4 - week values (p > 0.05). There was no statistically significant difference between the groups at both 4 and 8 weeks (p > 0.05). In the radiologically measured total bone volume values, PTH1-34 group values were found to be significantly higher for both 4 - and 8 - weeks values compared to the control groups (p < 0.05). Conclusion: In this study, rhPTH, which is used locally in defect areas to be repaired with bone grafts, increases both new bone volume and total bone volume. Keywords: Animal models; Bone grafting; Bone histomorphometry; Micro-computed tomography; Parathyroid hormone.tr_TR
dc.description.indexPubmed
dc.identifier.urihttps://doi.org/10.1016/j.aott.2019.08.007tr_TR
dc.identifier.urihttp://hdl.handle.net/20.500.12575/72282
dc.language.isoentr_TR
dc.relation.isversionof10.1016/j.aott.2019.08.007tr_TR
dc.relation.journalActa Orthop Traumatol Turc .tr_TR
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıtr_TR
dc.subjectAnimal modelstr_TR
dc.subjectBone graftingtr_TR
dc.titleLocally administrated single-dose teriparatide affects critical-size rabbit calvarial defects: A histological, histomorphometric and micro-CT studytr_TR
dc.typeArticletr_TR

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