Locally administrated single-dose teriparatide affects critical-size rabbit calvarial defects: A histological, histomorphometric and micro-CT study
| dc.contributor.author | Ocak, Mert | |
| dc.contributor.department | Sağlık Bilimleri Fakültesi | tr_TR |
| dc.date.accessioned | 2020-11-06T06:58:03Z | |
| dc.date.available | 2020-11-06T06:58:03Z | |
| dc.date.issued | 2019 | |
| dc.description.abstract | Objective: The aim of this study was to evaluate the effect of teriparatide (PTH 1-34, rhPTH) on a rabbit defect model with local xenogen grafts histomorphometrically and radiologically. Methods: For this purpose, two 10 mm diameter critical-size defects were created in the calvaria of 16 rabbits. In the control group, the defect area was filled with a xenogen graft, while in the teriparatide group (PTH 1-34), a xenogen graft combination with 20 mcg teriparatide was used. For both 4 - week and 8 - week study groups, new bone, residual graft, and soft tissue areas were evaluated as well as bone volume histomorphometrically and radiologically. Results: Histomorphometrically, there was a significant difference in new bone area values at the 8th week (p < 0.05), but there was no significant difference between the 4 - week values (p > 0.05). There was no statistically significant difference between the groups at both 4 and 8 weeks (p > 0.05). In the radiologically measured total bone volume values, PTH1-34 group values were found to be significantly higher for both 4 - and 8 - weeks values compared to the control groups (p < 0.05). Conclusion: In this study, rhPTH, which is used locally in defect areas to be repaired with bone grafts, increases both new bone volume and total bone volume. Keywords: Animal models; Bone grafting; Bone histomorphometry; Micro-computed tomography; Parathyroid hormone. | tr_TR |
| dc.description.index | Pubmed | |
| dc.identifier.uri | https://doi.org/10.1016/j.aott.2019.08.007 | tr_TR |
| dc.identifier.uri | http://hdl.handle.net/20.500.12575/72282 | |
| dc.language.iso | en | tr_TR |
| dc.relation.isversionof | 10.1016/j.aott.2019.08.007 | tr_TR |
| dc.relation.journal | Acta Orthop Traumatol Turc . | tr_TR |
| dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | tr_TR |
| dc.subject | Animal models | tr_TR |
| dc.subject | Bone grafting | tr_TR |
| dc.title | Locally administrated single-dose teriparatide affects critical-size rabbit calvarial defects: A histological, histomorphometric and micro-CT study | tr_TR |
| dc.type | Article | tr_TR |