Impact of“Killer Immunoglobulin-LikeReceptor /Ligand”Genotypes on Outcomefollowing Surgery among Patients withColorectal Cancer: Activating KIRs AreAssociated with Long-Term Disease FreeSurvival
| dc.contributor.author | Beksaç, Meral | |
| dc.contributor.author | Dalva, Klara | |
| dc.contributor.department | Tıp Fakültesi | tr_TR |
| dc.date.accessioned | 2020-02-20T14:24:40Z | |
| dc.date.available | 2020-02-20T14:24:40Z | |
| dc.date.issued | 2015 | |
| dc.description.abstract | Approximately 30%of patients with stage II/III colorectal cancer develop recurrence following surgery. How individual regulation of host mediated anti-tumor cytotoxicity is modified by the killer-cell immunoglobulin-like receptor (KIRs) genotype is essential for prediction of outcome. We analyzed the frequency of KIR and KIR ligand Human Leukocyte Antigen Class I genotypes, and their effects on recurrence and disease-free survival (DFS). Out of randomly selected 87 colorectal cancer patients who underwent R0 resection operations between 2005 and 2008, 29 patients whose cancers progressed within a median five-year follow-up period were compared with 58 patients with no recurrence within the same time period. Recurrent cases shared similar tumor stages with non-recurrent cases, but had different localizations.We used DNA isolated from pathological archival lymphoid and tumor tissues for KIR and KIR ligand (HLA-C, group C1, group C2, and HLA-A-Bw4) genotyping. Among cases with recurrence, KIR2DL1 (inhibitory KIR) and A-Bw4 (ligand for inhibitory KIR3DL1) were observed more frequently (p=0.017 and p=0.024); and KIR2DS2 and KIR2DS3 (both activating KIRs) were observed less frequently (p=0.005 and p=0.043). Similarly, in the non-recurrent group, inhibitory KIR-ligand combinations 2DL1-C2 and 2DL3-C1 were less frequent, while the activating combination 2DS2-C1 was more frequent. The lack of KIR2DL1, 2DL1-C2, and 2DL3-C1 improved disease-free survival (DFS) (100% vs. 62.3%, p=0.05; 93.8% vs. 60.0%, p=0.035; 73.6% vs. 55.9%, p=0.07). The presence of KIR2DS2, 2DS3, and 2DS2-C1 improved DFS (77.8% vs. 48.5%, p=0.01; 79.4% vs. 58.5%, p=0.003; 76.9% vs. 51.4%, p=0.023). KIR2DS3 reduced the risk of recurrence (HR=0.263, 95% CI = 0.080-0.863, p=0.028). The number of activating KIRs are correlated strongly with DFS, none/ one/ two KIR: 54/77/98 months (p=0.004). In conclusion the inheritance of increasing numbers of activating KIRs and lack of inhibitory KIRs, independent of tumor localization or stage, is associated with long-term DFS. | tr_TR |
| dc.description.index | Wos | |
| dc.description.index | Scopus | |
| dc.identifier.endpage | 11 | tr_TR |
| dc.identifier.issn/e-issn | 1932-6203 | |
| dc.identifier.issue | 7 | tr_TR |
| dc.identifier.other | e0132526 | tr_TR |
| dc.identifier.startpage | 01 | tr_TR |
| dc.identifier.uri | https://doi.org/10.1371/journal.pone.0132526 | tr_TR |
| dc.identifier.uri | http://hdl.handle.net/20.500.12575/69902 | |
| dc.identifier.volume | 10 | tr_TR |
| dc.language.iso | en | tr_TR |
| dc.relation.isversionof | 10.1371/journal.pone.0132526 | tr_TR |
| dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | tr_TR |
| dc.rights | CC0 1.0 Universal | * |
| dc.rights.uri | http://creativecommons.org/publicdomain/zero/1.0/ | * |
| dc.title | Impact of“Killer Immunoglobulin-LikeReceptor /Ligand”Genotypes on Outcomefollowing Surgery among Patients withColorectal Cancer: Activating KIRs AreAssociated with Long-Term Disease FreeSurvival | tr_TR |
| dc.type | Article | tr_TR |