Browsing by Author "Vural, Sevil Atalay"

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    Anal sac carcinoma in a dog
    Vural, Sevil Atalay
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    Comparison of periapical radiography, panoramic, and cone-beam CT in the detection of dental caries in dog teeth
    (Ankara Üniversitesi, 2019-09-09) Orhan, Kaan; Özemre, Mehmet Özgür; Seçgin, Cansu Köseoğlu; Vural, Sevil Atalay; Gür, Gürkan; Kamburoğlu, Kıvanç; Veteriner Fakültesi
    The aim of this study was to compare the effectiveness of panoramic, periapical and two different Cone Beam Computed Tomography (CBCT) devices in the detection of dental caries of dog teeth ex vivo. A total of 880 teeth were investigated, 33 of which were with caries, whereas; 33 healthy teeth were the controls. Periapical, panoramic and CBCT scans were made for the assessment of the teeth. All images were evaluated separately by two observers experienced in image interpretation. The presence or absence of occlusal caries was scored using a 5-point scale. Kappa values were calculated to assess intra and interobserver agreement. Receiver Operating Characteristic (ROC) analysis was performed to compare the effectiveness of different imaging methods in the detection of dental caries. For both observers, the order of success of the image sets in the estimation of the caries tooth was CBCT Morita, CBCT Iluma, periapical and panoramic radiograph (Area Under Curve (AUC): 0.929, 0.882, 0.861, and 0.704 for observer 1, AUC: 0.927, 0.896, 0.875, and 0.693 for observer 2, respectively). CBCT was found to be the best imaging method for the ex vivo detection of caries in dog teeth. In addition, panoramic images performed worse than all other modalities.
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    Pegylated interferon-alpha plus taurine in treatment of rat liver fibrosis
    (2007) Bozdayı, Abdurrahman; Yurdaydın, Cihan; Bozkaya, Hakan; Vural, Sevil Atalay; Alçığır, Günay; Veteriner Fakültesi
    AIM: To investigate the antifibrotic effects of peginterferon-alpha 2b and taurine on oxidative stress markers and hepatocellular apoptosis. METHODS: Sixty rats with CCl4-induced liver fibrosis were divided into 4 groups (n = 15). Group 1 was left for spontaneous recovery (SR). Groups 2-4 received peginterferon-alpha 2b, taurine, and their combination, respectively, for four weeks. Histological fibrosis scores, histomorphometric analysis, tissue hydroxyproline, tissue MDA, GPx and SOD activities were determined. Activated stellate cells and hepatocellular apoptosis were also evaluated. RESULTS: The degree of fibrosis decreased in all treatment groups compared to spontaneous recovery group. Taurine alone and in combination with peginterferon-alpha 2b reduced oxidative stress markers, but peginterferon-alpha 2b alone did not. Apoptotic hepatocytes and activated stellate cells were higher in groups 2-4 than in group 1. Combined taurine and peginterferon-alpha 2b further reduced fibrosis and increased activated stellate cell apoptosis, but could not improve oxidative stress more than taurine alone. CONCLUSION: Peginterferon-alpha 2b exerts anti-fibrotic effects on rat liver fibrosis. It seems ineffective against oxidative stress in vivo. Peginterferon-alpha 2b in combination with taurine seems to be an antifibrotic strategy.