Browsing by Author "Ural, Kerem"

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    Demodicosis in a Golden (Syrian) hamster (Mesocricetus auratus)
    (2009) Karaer, Zafer; Kurtdede, Arif; Ural, Kerem; Sarı, Barış; Cıngı, C. Çağrı; Karakurum, M. Çağrı; Haydardedeoğlu, A. Evren
    A two year old male Golden (Syrian) hamster (Mesocricetus auratus) was presented with a history of alopecia on the dorso-lumbosacral area and on the back, lethargy, anorexia and severe pruritus. Microscopic examination of skin scraping revealed mites identified as Demodex criceti and Demodex aurati. Initial therapy included ivermectin and H-vitamin, neverthless the present case was dead four days after admission. To the present authors’ knowledge this is the first reported case describing the mix demodectic infestation by Demodex criceti and Demodex aurati, in Syrian hamster in Turkey. Bu olgunun materyalini, dorso-lumbosakral bölge ve sırtta alopesi, letarji, anoreksi ve aşırı kaşıntı öyküsü olan 2 yaşlı erkek bir Golden (Syrian) hamster (Mesocricetus auratus) oluşturdu. Deri kazıntısının mikroskobik muayenesinde Demodex criceti ve Demodex aurati görüldü. İvermektin ve H-vitamini ile yapılan sağaltıma karşın hasta dört gün sonra öldü. Bu olgu sunumunda Türkiye’de ilk defa bir Suriye hamsterinde Demodex criceti ve Demodex aurati’nin oluşturduğu miks demodikozis tanımlanmıştır.
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    Fecal microbiota transplantation capsule therapy via oral route for combatting atopic dermatitis in dogs
    (Ankara Üniversitesi Veteriner Fakültesi, 2022) Ural, Kerem; Other; Other
    Given the role of the interaction between gut microbiome with dermatological diseases, namely “gut-skin axis”, the present author proved that gut restoration should alleviate canine atopic dermatitis (CAD), which was the purpose of the study. A 4-week, open-label, non-controlled case series involved 8 -owned dogs with CAD which had received no previous treatment. Evaluations included Canine Atopic Dermatitis Extent and Severity Index version 4 (CADESI-04 scores), Visual Analog Scale (VAS) pruritus scores and Polycheck in vitro allergen specific tests. Faecal samples were analysed by dual indexing one-step PCR and 16S rRNA targeted metagenomics for detecting gut microbiota alterations before and after fecal microbiota transplantation (FMT) capsule treatment twice daily for 4 weeks. All cases were presenting pruritus and all of those dogs showed elevated IgE levels. CADESI scores decreased on days 28 (4-21) compared to day 0 initial values (50-128). Similarly, decreased VAS scores were detected on days 28 (0-2) in contrast to prior values (6-10). Regarding epidermal barrier functioning epidermal hydration (55-100 vs. 4-24) and pH (6.-7.8 vs. 4.2-5.7) values were elevated after FMT treatment in contrast to prior ranges, respectively. Alpha diversity revaled both richness and diversity of gut microbiota were improved for all cases on day 28. Furthermore at the end of trial Firmicutes: Bacteroidetes ratio was 8, the benchmark detected for healthy dogs. The present study supports a potential benefit of FMT capsule treatment against CAD. This safe and tolerant treatment modality directed against CAD shifted the gut microbiome composition towards a healthy state for all 8 dogs enrolled.
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    Hemobartonellozisli kedilerde klinik, hematolojik bulgular, FIV/FeLV infeksiyonları ile ilişkisi, sağaltımda enrofloksasin uygulamaları
    (Sağlık Bilimleri Enstitüsü, 2006) Ural, Kerem; Kurtdede, Arif; Veteriner Hekimliği
    49SUMMARYClinical, Haematological Signs, Association with FIV/FeLV Infections in Cats withHaemobartonellosis and Enrofloxacin Application in TherapyThe material of the present study constituted 12 out of 39 cats, referred to the University of Ankara,Faculty of Veterinary, Department of Internal Medicine, with Haemobartonella felis diagnosed on bloodsmears in which have at least one of the clinical sings related to probable haemobartonellosis such as fleainfestation, elavated body temperature, absscess formation related to fighting, continual outdoor roaming,anaemia, icterus, bronchitis and lmyphadeopathy. Diagnosis was confirmed by PCR in those 12 cats. Thepresent cats were aged between 1-10 years, 2 Persian, 3 Ankara and 8 cross breeds, of 4 female and 8male.Clinical examination was performed in cats constituting the survey and before (day 0) and aftertherapy (day 60) blood was withdrawn from vein cephalica antebrachii for 2 times for haematologicalexamination, PCR assays and biochemical examinations and blood smear was performed from fresh bloodon the patient.Primers were used targetting the 16S rRNA gene, producing a 170 base pair product fromMycoplasma haemofelis and 193 base pair product from Candidatus Mycoplasma haemominutum with 5?-ACG AAA GTC TGA TGG AGC AAT A-3? forward primer and 5?- ACG CCC AAT AAA TCC GRATAA T-3? reverse primers.In 9 of cats elavated body temperature, flea infestation in 9, tick infestation in 1, anorexia in 8,pale mucosae in 8, tachypnea in 6, dispnoea in 5, tachycardia in 4, dehydration in 4, respiratory distress in4, icterus in 3 and splenomegali in 3 cats were detected.Decreased haemoglobin in 12, decreased erythrocyte in 7, decreased hematocrite in 7 cats,increased AST and ALT in 7, bilirubin in 5 and urea in 4 cats, leucocytosis in 3 and leucopenia in 1 catwere detected.Haemobartonella sp. was diagnosed in all of the cats within the cytological examination of bloodsmears. The presence of Candidatus Mycoplasma haemominutum was detected by PCR.In 4 cats out of 12 with a diagnosis of haemobartonellosis FIV antibodies were detected.Blood smear examination, PCR assay and haematological examination results obtained on day 60following therapy with enrofloxacin at a dosage of 5 mg/kg subcutaneously for 10 days suggested theefficacy of the antibiotic for the clearence of organism from the erythrocyte.As a result in cats with suspected hemobartonellosis on the basis of history and clinicalexamination, the causitive agent can be observed on cytological examination of blood smears, definitivediagnose and strain detection can be done by use of PCR assay, FIV can be detected as an co-infection inill cats and enrofloxacin was suggested to be effective at therapy.Key Words: 1-Cat 2- Haemobartonellosis 3-FIV 4-FeLV infection 5-Enrofloxacin