Browsing by Author "Uncu, Nermin"

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    Assessment of Neutrophil to Lymphocyte Ratio and Mean Platelet Volume in Pediatric Familial Mediterranean Fever Patients
    (A publication of Isfahan University of Medical Sciences, 2017-03-15) Başaran, Özge; Uncu, Nermin; Çelikel Acar, Banu; Aydın, Fatma; Cakar, Nilgun; orcid.org/0000-0002-1853-0101; Tıp Fakültesi
    Abstract Background:Blood neutrophil to lymphocyte ratio (NLR) and mean platelet volume (MPV) both have been used as a simple marker of inflammation in many disorders. Here, we aimed to investigate the relationship between NLR, MPV, and familial Mediterranean fever (FMF). Materials and Methods:In this retrospective study, the files of FMF patients in pediatric rheumatology outpatient clinic were reviewed. There were 160 participants (68.4%) in the FMF patient group and 74 participants (31.6%) in the control group. Ninety of patients were in attack-free period, and 70 were in attack period. Results:The highest values of NLR were found in the patients at attack period. Patients in attack-free period and the participants in control group had similar levels of NLR (1.71 ± 0.83 and 1.91 ± 1.86 respectively) (P = 0.457), and they had lower ratios than the patients did at attack period (4.10 ± 3.11) (P < 0.001 for both). There was no significant difference between MPV values of attack patients (8.35 ± 4.91) and attack-free patients (8.43 ± 1.15) (P = 0.074). MPV values of attack patients and attack-free patients were significantly higher than control group (7.99 ± 0.81) (P < 0.001 for both). Conclusion:NLR ratio may indicate FMF attack period. Since there was no significant difference between attack-free patients and control groups, NLR ratio cannot be used as a subclinical inflammation marker. However, NLR could be a useful predictor of inflammation in FMF patients. On the other hand, since our attack and attack-free patients have similar MPV values and both had greater MPV values than control group, we suggest that MPV may be used to show subclinical inflammation.
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    Cytomegalovirus-related Hemorrhagic Cystitis in an Immunocompetent Child
    (Informa Healthcare, 2014-08) Taktak, Aysel; Acar, Banu; Gür, Gökçe; Tiryaki, Tuğrul; Karakuş, Esra; Çaycı, Fatma Şemsa; Uncu, Nermin; Çakar, Nilgün; https://orcid.org/0000-0002-1853-0101; Tıp Fakültesi
    Abstract Cytomegalovirus (CMV) infections are mostly seen in immunocompromised patients. However,unusual manifestations or complications of acquired CMV infections in immunocompetent patients are rarely reported. CMV-related hemorrhagic cystitis is extremely rare but should be considered even in immunocompetent patients. We present a case of a 3-year-old immunocompetent boy with intermittent, terminal gross hematuria lasting for 1 month. There was no history of genitourinary trauma or stone disease. Urine analysis revealed hematuria with eumorphic red blood cells and no proteinuria. Urine culture was negative. Ultrasonography showed increased bladder wall thickness and irregularity at inferior of bladder. Cystoscopy revealed hyperemia and edema. Histopathological examination was consistent with CMV infection, viral DNA by polymerase chain reaction in peripheral blood and urine were positive. Clinical, laboratory, and imaging features pointed towards hemorrhagic cystitis due to CMV. He was followed-up with no treatment. After 1 month, repeated investigations showed complete resolution of finding. This is a rare description of an immunocompetent child with CMV-induced cystitis.