Browsing by Author "Torğutalp, Murat"

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    Antiphospholipid antibodies and non-thrombotic manifestations of systemic lupus erythematosus
    (SAGE Publications Ltd, 2018) Kınıklı, Gülay; Dinçer, Ayşe Bahar Keleşoğlu; Tıp Fakültesi; İlgen, Ufuk; Yayla, Müçteba Enes; Ateş, Aşkın; Okatan, İ. E.; Yurteri, Emine uslu; Torğutalp, Murat; Turgay, Tahsin Murat
    Objectives: The aim of this study was to investigate the association between antiphospholipid antibodies and non-thrombotic and non-gestational manifestations of systemic lupus erythematosus. Methods: Systemic lupus erythematosus patients with persistently positive antiphospholipid antibodies or lupus anticoagulant were identified and grouped as systemic lupus erythematosus with antiphospholipid syndrome (SLE-APS), systemic lupus erythematosus with positive antiphospholipid antibodies/lupus anticoagulant without antiphospholipid syndrome (SLE-aPL), and systemic lupus erythematosus with negative aPLs (SLE-No aPL). Groups were compared in terms of non-thrombotic systemic lupus erythematosus manifestations and laboratory features retrospectively. Results: A total of 150 systemic lupus erythematosus patients, 26 with SLE-APS, 25 with SLE-aPL, and 99 with SLE-No aPL, were identified. Livedo reticularis, neurologic involvement, and thrombocytopenia were more common in antiphospholipid antibody positive systemic lupus erythematosus cases. Malar rash, arthritis, and pleuritis were more common in the SLE-No aPL, SLEAPS, and SLE-aPL groups, respectively. Positivity rates and titers of specific antiphospholipid antibodies did not differ between the SLE-APS and SLE-aPL groups. Conclusions: Presence of antiphospholipid syndrome or persistent antiphospholipid antibodies may be related to non-thrombotic and non-gestational systemic lupus erythematosus manifestations. Patients with systemic lupus erythematosus plus antiphospholipid syndrome and persistent antiphospholipid antibodies without antiphospholipid syndrome also differ in terms of systemic lupus erythematosus manifestations.
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    Association of simple hematological parameters with disease manifestations, activity, and severity in patients with systemic sclerosis
    (Springer Nature, 2020) Kınıklı, Gülay; Tıp Fakültesi; Yayla, Müçteba Enes; Okatan, İlyas Ercan; Yurteri, Emine uslu; Dinçer, Ayşe Bahar Keleşoğlu; Torğutalp, Murat; Gülöksüz, Emine Gözde Aydemir; Sezer, Serdar; Turgay, Tahsin Murat; Ateş, Aşkın
    Introduction/objectives Neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), mean platelet volume (MPV),andredcelldistributionwidth(RDW)maypotentiallyreflectinflammatorystatusinsystemicautoimmunediseases.The aim of this study is to investigate the association between these proposed markers and disease manifestations, activity, and severity in systemic sclerosis (SSc). Method We conducted a cross-sectional study of 69 systemic sclerosis (SSc) patients and 50 healthy volunteers in a single center. Adult patients with SSc and healthy controls were compared in terms of NLR, MLR, MPV, RDW, erythrocyte sedimentation rate (ESR),andC-reactiveprotein(CRP).Venousbloodsamplesweredrawnafteratleast8hoffastinginthemorning.Extensionofskin fibrosiswasevaluatedbyusingmodifiedRodnanskinscore(mRSS).DiseaseseverityandactivitywereassessedbyMedsgerdisease severityandEuropeanSclerodermaTrialsandResearchGroup(EUSTAR)diseaseactivityscores,respectively.Associationsofdisease manifestations,clinical,laboratory,andcapillaroscopicfindings,mRSS,andthediseaseactivityandseverityscoreswiththeproposed hematological markers were evaluated. Multiple regression models were generated for significant associations. Results Theneutrophilnumberwashigher(p=0.004)andlymphocytenumberwaslower(p<0.001)inSScgroupcomparedto controls. SSc group also had higher NLR, MLR, and RDW. In multiple logistic regression, only the NLR (regression coefficient=3.49, p=0.031) and CRP (regression coefficient=0.17, p=0.037) remained significantly different between SSc and healthy control groups (Cox and SnellR2 =0.243,NagelkerkeR2 =0.337,p<0.001). NLR and MLR positively correlated with mRSS, EUSTAR score, and CRP. MLR also positively correlated with Medsger score. Higher monocyte counts independently predicted higher EUSTAR and Medsger scores in multiple linear regressions. Patients with digital ulcers had higher NLR and MLR. We did not find any difference in MPV values between SSc and healthy control groups. Conclusions Globally available and inexpensive hematological tests, particularly the NLR and MLR, may be associated with vascular and cutaneous manifestations as well as disease activity and severity in SSc.