Browsing by Author "Pekcan, Zeynep"

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    Effects of epidural bupivacaine, bupivacaine-butorphanol and bupivacaine-morphine on postoperative analgesia for hind limb and pelvic orthopedic operations in dogs
    (Ankara Üniversitesi, 2020-12-25) Karslı, Birkan; Pekcan, Zeynep; Kumandaş, Ali; Kürüm, Barış; Çınar, Miyase; Veteriner Fakültesi
    The aim of this study was to compare the postoperative analgesic effects of epidural bupivacaine, bupivacaine-butorphanol and bupivacaine-morphine in hind limb and pelvic orthopedic operations in dogs. Three groups each containing 10 dogs were formed. Through the lumbosacral space, group B was administered bupivacaine, 1 mg kg-1; group BB was administered bupivacaine, 1 mg kg-1 and butorphanol, 0.25 mg kg-1; and group BM was administered bupivacaine, 1 mg kg-1 and morphine, 0.1 mg kg-1. Anaesthesia was induced with diazepam (0.2 mg kg-1) and propofol (5 mg kg-1) and maintenance with isoflurane in oxygen. Pain assessment was performed with the University of Melbourne Pain Scale (UMPS) by a blinded observer. Plasma cortisol levels were measured preoperatively and postoperatively. Postoperative pain scores were significantly lower at 2 hours in the group BM, and at 8 and 12 hours in the groups BB and BM compared to the group B (P=0.007). Group BM had a lower plasma cortisol level than the group B at 2 hours (P=0.002). Bupivacaine-butorphanol and bupivacaine-morphine use were shown to provide longer analgesia in the postoperative period; and the epidural administration of bupivacaine-butorphanol and bupivacaine-morphine was considered to be potentially useful in clinical practice.
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    Köpeklerde epidural morfin ile fentanil bantın postoperatif analjezi üzerine etkileri
    (Sağlık Bilimleri Enstitüsü, 2005) Pekcan, Zeynep; Koç, Bahattin
    Çalışmanın amacı epidural morfin ve fentanil bantın kalp frekansı, solunum sayısı, kan basıncı, vücut sıcaklığı ve analjezi üzerine etkisini incelemektir. 30 dişi melez köpek çalışma materyalini oluşturdu. Köpekler epidural morfin, fentanil bant ve kontrol grubu olmak üzere rastgele 10'arlı üç gruba ayrıldı. Propofol indüksiyonundan sonra hayvanlar entübe edilerek izofloran ile anesteziye devam edildi. Epidural morfin grubundaki köpeklere 0.1 mg/kg dozundaki morfin seyreltilerek Tuohy iğnesi ile epidural boşluğa enjekte edildi. Fentanil bant grubundaki köpeklere ise bantları operasyondan 24 saat önce yapıştırılırken, kontrol grubundaki köpeklere ise hiçbir analjezik madde uygulanmadı. Operasyon esnasında sistemik arteriyel kan basıncının monitörizasyonu için femoral arter kateterize edildi. Tüm köpeklere ovariohisterektomi operasyonu yapıldı. Operasyondan sonra 0., 30., 60., 90., 120., 150. dakikalarda; 3., 4., 5., 6., 8., 10., 12. ve 24. saatlerde köpeklerin analjezi skorları, kalp frekansı, solunum sayısı, kan basıncı ve vücut sıcaklığı değerleri kaydedildi. Plazma kortizol ölçümü için operasyondan önce, 0., 2., 4., 6., 12. ve 24. saatlerde kan örnekleri alındı. Ağrı skorunun epidural grubundaki köpeklerde fentanil ve kontrol grubundakilerden daha düşük olduğu, fentanil grubunun ise kontrol grubundan daha düşük olduğu kaydedildi. Erken postoperatif dönemde fentanil grubundaki köpeklerin diğer gruptakilerden daha huzursuz olduğu kaydedilirken; 4. saatten sonra ise epidural grubundakilerden daha halsiz olduğu gözlendi. 0. saatte tüm gruplarda kalp frekansı yüksek bulunurken, kontrol grubunda ilerleyen periodlarda da yüksek kaldığı kaydedildi. Erken postoperatif dönemde tüm gruplarda plazma kortizol konsantrasyonu yüksek bulurken, fentanil grubundaki köpeklerin diğer gruptakilerden daha yüksek olduğu tespit edildi. Epidural grubunda kortizol değerlerinin 6 saat içinde, fentanil ve kontrol grubunda ise 12 saat içinde normal sınırlara indiği tespit edildi. Sonuç olarak, köpeklerde epidural morfin enjeksiyonunun fentanil bant uygulamasından daha iyi analjezi sağladığı ve rutin olarak uygulanabileceği saptandı. AbstractThe purpose of the study was to investigate the effects of epidural morphine and fentanyl patch on heart rate, respiratory rate, blood pressure, body temperature and analgesia score. 30 mongrel female dogs were included in this study. Three groups were constituted, named; epidural morphine, fentanyl patch and control groups. Following induction with propofol, the dogs were intubated and anesthesia was maintained with isoflorane in oxygen. After a stable plane of anesthesia was achieved, morphine (0.1 mg/kg) was diluted with normal saline solution and administered through the Tuohy needle in the epidural morphine group. Fentanyl patch was applied 24 hours before the operation in the fentanyl patch group and no analgesics was administered to the control group. Femoral artery was catheterized for continuous measurement of systemic arterial blood pressure during the operation. Ovariohysterectomy operation was performed to all dogs. After the operation analgesic scores, heart rate, respiratory rate, blood pressure and body temperature were recorded at 0., 30., 60., 90., 120., 150. minutes; 3., 4., 5., 6., 8., 10., 12. and 24. hours. Blood samples were collected preoperatively and at 0., 2., 4., 6., 12. and 24. hours for cortisol measurements. Pain score were significantly lower in the dogs in the epidural group than the fentanyl and control group; also the pain score were low in fentanyl group when compared with the control group. In the early postoperative period the fentanyl group were more agitated than the other groups and the dogs in the fentanyl group were more sedated than the dogs in the epidural group after the 4th hour. Heart rates were high at the 0. hour in all groups and continued high in the control group in the latter period. Plasma cortisol concentrations were high in the early postoperative period. Dogs in the fentanyl group had higher cortisol concentrations than those in the epidural or control group. Plasma cortisol concentrations were within reference range by 6 hour in the epidural group and by 12 hour in the fentanyl and control group. In conclusion, epidurally administered morphine maintained better analgesia than fentanyl patch in dogs and can be administered routinely.
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