The molecular mechanisms of the effect of anticancer activity on lichen metabolites

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dc.contributor.authorDuman, Demet Cansaran
dc.contributor.authorIDhttp://orcid.org/0000-0001-5662-2333tr_TR
dc.contributor.departmentBiyoteknoloji Enstitüsütr_TR
dc.contributor.otherŞekerli, Merve
dc.contributor.otherKılıç, Nil
dc.date.accessioned2020-05-08T07:48:01Z
dc.date.available2020-05-08T07:48:01Z
dc.date.issued2017
dc.description.abstractThe components obtained from natural products have been used in many fields such as medicine, pharmacy and biology throughout the history. Some important new commercial drugs have been obtained from natural molecule using as a model in the cancer field. Studies for the development of cytotoxic agents were an important step for the discovery of new anticancer drugs. Large structural diversity of natural components and their bioactivity potential may serve to improve the therapeutic potential with molecular modification. The number of studies on the anticancer activity of lichen components has increased in last few years. Lichens are symbiotic organisms of fungus and algae or cyanobacteria. Lichens synthesize a great variety of secondary metabolites. Lichen secondary compounds have many possible biological activities such as antiviral, antitumor, antibacterial and antiherbivore and antioxidants. In recent years, one of the most important features of lichen secondary metabolites will also be candidate molecules in the treatment of anticancer therapy in the medical and biotechnology studies. Elucidation of the molecular basis of cancer related processes and also apoptosis pathway are provide to great utility in finding alternative drugs for treating cancer. In this review research the knowledge about lichen secondary metabolites, the potential for effective use in the treatment of cancer, all molecular mechanisms in cancerous processes and mainly apoptosis pathway.tr_TR
dc.identifier.endpage102tr_TR
dc.identifier.issue1tr_TR
dc.identifier.startpage95tr_TR
dc.identifier.urihttps://doi.org/10.5505/TurkHijyen.2016.24650tr_TR
dc.identifier.urihttp://hdl.handle.net/20.500.12575/71225
dc.identifier.volume74tr_TR
dc.language.isoentr_TR
dc.relation.isversionof10.5505/TurkHijyen.2016.24650tr_TR
dc.relation.journalTurk Hijyen ve Deneysel Biyoloji Dergisitr_TR
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıtr_TR
dc.subjectCancertr_TR
dc.subjectLichen secondary metabolitestr_TR
dc.subjectMolecular mechanismstr_TR
dc.titleThe molecular mechanisms of the effect of anticancer activity on lichen metabolitestr_TR
dc.title.alternativeLiken metabolitlerinin antikanser aktivite etkisinin moleküler düzeydeki mekanizmalaritr_TR
dc.typeArticletr_TR

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