Serum interleukin-35 and pentraxin-3 levels in patients with mild acute pancreatitis

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dc.contributor.authorDoğan, Özlem
dc.contributor.departmentTıp Fakültesitr_TR
dc.date.accessioned2020-11-13T06:12:12Z
dc.date.available2020-11-13T06:12:12Z
dc.date.issued2019
dc.description.abstractIntroduction: Interleukin-35 (IL-35) is a newly defined potent anti-inflammatory cytokine that is predominantly produced by regulatory T cells, and pentraxin-3 belongs to the acute-phase proteins. Aim: To measure the serum IL-35 and pentraxin-3 levels in the early phase of mild acute pancreatitis (AP). Material and methods: Eighty-three patients with mild AP and 30 healthy controls were included in the study. The serum levels of IL-35 and pentraxin-3 were measured by enzyme-linked immunosorbent assay upon admission and at the 48th hour after diagnosis. Results: The mean value of serum IL-35 levels in patients with mild acute pancreatitis at admission was 5.91 ng/ml (4.21-7.90) and was significantly lower than those in healthy controls (25.53 ng/ml (12.79-54.73, p < 0.001)) and 48-hour value were (6.79 ng/ml (4.42-9.62) (p = 0.015)). The mean value of serum pentraxin-3 levels in patients at the time of admission was 6.75 ng/ml (4.42-9.62) and there was no significant difference from healthy controls, at 7.64 ng/ml (6.58-8.62, p > 0.05). Also there was no significant difference between the mean value at admission and the mean value at 48-hour, 6.75 ng/ml (4.74-9.06, p > 0.05). Conclusions: Interleukin-35 can be used in diagnosis and follow-up in patients with mild AP.tr_TR
dc.description.indexPubmed
dc.identifier.endpage54tr_TR
dc.identifier.issue1tr_TR
dc.identifier.startpage48tr_TR
dc.identifier.urihttps://doi.org/10.5114/pg.2019.83425tr_TR
dc.identifier.urihttp://hdl.handle.net/20.500.12575/72369
dc.identifier.volume14tr_TR
dc.language.isoentr_TR
dc.relation.isversionof10.5114/pg.2019.83425tr_TR
dc.relation.journalPrz Gastroenterol .tr_TR
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıtr_TR
dc.subjectinterleukin-35tr_TR
dc.subjectmild acute pancreatitistr_TR
dc.titleSerum interleukin-35 and pentraxin-3 levels in patients with mild acute pancreatitistr_TR
dc.typeArticletr_TR

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