The research of 1,2,4-triazole derivatives hepatoprotective activity under tetracycline and infectious hepatitis

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dc.contributor.authorShcherbyna, Roman
dc.contributor.authorVashchyk, Yevgenia
dc.contributor.authorIDhttps://orcid.org/0000-0002-9742-0284tr_TR
dc.contributor.departmentEczacılık Fakültesitr_TR
dc.date.accessioned2020-04-01T08:58:41Z
dc.date.available2020-04-01T08:58:41Z
dc.date.issued2019
dc.description.abstractObjective: The purpose of this work is to study the hepatoprotective properties of potassium 2-((4-amino5-(morpholinomethyl)-4H-1,2,4-triazole-3-yl)thio)acetate on tetracycline and infectious hepatitis models in chickens. Material and Method: Biochemical examination of blood and liver serum was carried out on intact broiler chickens Cross Cobb 500. All groups of chickens were kept separately in different cages in the same room with the same microclimate parameters in accordance with the established requirements. Result and Discussion: Hepatoprotective effect of potassium 2-((4-amino-5-(morpholinomethyl)-4H1,2,4-triazole-3-yl)thio)acetate was established as a result of research on the model of hepatitis in chickens caused by tetracycline, which was not lower than the referent drug - Thiotriazolin®. The biochemical study results demonstrated hepatoprotective properties of the combination of the above compound with the antibiotic Saroflox®, combination of potassium 2-((4-amino-5- (morpholinomethyl)-4H-1,2,4-triazole-3-yl) thio) acetate with classical antibiotic Enrofloxacin® on the model of infectious hepatitis.tr_TR
dc.identifier.endpage146tr_TR
dc.identifier.issn/e-issn1015-3918
dc.identifier.issue02tr_TR
dc.identifier.startpage135tr_TR
dc.identifier.urihttps://doi.org/10.33483/jfpau.487173tr_TR
dc.identifier.urihttp://hdl.handle.net/20.500.12575/70849
dc.identifier.volume43tr_TR
dc.language.isoentr_TR
dc.publisherAnkara : Ankara Üniversitesitr_TR
dc.relation.isversionof10.33483/jfpau.487173tr_TR
dc.relation.journalAnkara Üniversitesi Eczacılık Fakültesi Dergisitr_TR
dc.relation.publicationcategoryMakale - Ulusal - Editör Denetimli Dergi - Başka Kurum Yazarıtr_TR
dc.subjectBiochemical indicatorstr_TR
dc.subjectHepatoprotective activittr_TR
dc.titleThe research of 1,2,4-triazole derivatives hepatoprotective activity under tetracycline and infectious hepatitistr_TR
dc.title.alternativeTetrasiklin ve infeksiyöz hepatit şartları altında 1,2,4-triazol türevlerinin karaciğer koruyucu aktivitelerinin araştırılmasıtr_TR
dc.typeArticletr_TR

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Cilt:43 Sayı:02 (2019)