Diagnostic and Prognostic Role of Serum Interleukin-6 in Malignant Transformation of Liver Cirrhosis
| dc.contributor.author | Özkan, Hasan | |
| dc.contributor.department | Tıp Fakültesi | tr_TR |
| dc.date.accessioned | 2021-01-05T07:36:19Z | |
| dc.date.available | 2021-01-05T07:36:19Z | |
| dc.date.issued | 2018 | |
| dc.description.abstract | Aim: Alpha-fetoprotein (AFP) is still the most commonly used and the single most recommended marker in the diagnosis of hepatocellular carcinoma (HCC). Interleukin (IL)-6 is a circular cytokine and its role on carcinogenesis in various hematological and solid tumors is clearly documented. A combination of serum IL-6 and AFP may provide beneficial information regarding early diagnosis of HCC. In this study, the effect of plasma IL-6 level in the diagnosis of HCC was investigated. Materials and methods: A total of 130 patients with liver cirrhosis, together with 30 control cases were enrolled in the trial. A diagnosis of HCC was present in 75 patients (57.6%) in the liver cirrhosis group. Blood samples were obtained from the enrolled study and control cases. Alpha-fetoprotein was quantified by chemiluminescent method. Plasma IL-6 levels of samples obtained at -80°C were quantified by human IL-6 BMS213/2 BMS213/2TEN kit. Results: The HCC patients were older than the patients in the cirrhosis group (p = 0.016). On comparison of the HCC patients with the control group, AFP (p < 0.001) and IL-6 (p < 0.001) were significantly higher among the HCC patients. Comparison of HCC patients with liver cirrhosis cases with no diagnosis of HCC revealed significantly high AFP (p < 0.001) and IL-6 levels (p < 0.001) in HCC group. Cutoff value for IL-6 was calculated as 5.73 (pg/mL). No difference was detected in AFP (p = 0.600) and IL-6 (0.344) in all three subgroups. A total of 17 patients died during a mean follow-up period of 32.9 months. No correlation was found between mean AFP values and IL-6 values and survival rates. Conclusion: Plasma IL-6 level was found to be significant in the diagnosis of HCC. Alpha-fetoprotein and IL-6 provided no advantage in terms of early diagnosis of HCC and no correlation was observed between these markers and survival.How to cite this article: Yakut M, Özkan H, Karakaya MF, Erdal H. Diagnostic and Prognostic Role of Serum Interleukin-6 in Malignant Transformation of Liver Cirrhosis. Euroasian J Hepato-Gastroenterol 2018;8(1):23-30. | tr_TR |
| dc.description.index | Pubmed | |
| dc.identifier.endpage | 30 | tr_TR |
| dc.identifier.issue | 1 | tr_TR |
| dc.identifier.startpage | 23 | tr_TR |
| dc.identifier.uri | https://doi.org/10.5005/jp-journals-10018-1253 | tr_TR |
| dc.identifier.uri | http://hdl.handle.net/20.500.12575/72621 | |
| dc.identifier.volume | 8 | tr_TR |
| dc.language.iso | en | tr_TR |
| dc.relation.isversionof | 10.5005/jp-journals-10018-1253 | tr_TR |
| dc.relation.journal | Euroasian J Hepatogastroenterol . | tr_TR |
| dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | tr_TR |
| dc.subject | Cirrhosis | tr_TR |
| dc.subject | Diagnosis | tr_TR |
| dc.subject | Hepatocellular carcinoma | tr_TR |
| dc.title | Diagnostic and Prognostic Role of Serum Interleukin-6 in Malignant Transformation of Liver Cirrhosis | tr_TR |
| dc.type | Article | tr_TR |