Toxoplasmosis in Transplant Recipients, Europe, 2010–2014

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dc.contributor.authorAkan, Hamdi
dc.contributor.departmentTıp Fakültesitr_TR
dc.date.accessioned2020-12-21T11:16:45Z
dc.date.available2020-12-21T11:16:45Z
dc.date.issued2018
dc.description.abstractTransplantation activity is increasing, leading to a growing number of patients at risk for toxoplasmosis. We reviewed toxoplasmosis prevention practices, prevalence, and outcomes for hematopoietic stem cell transplant (HSCT) and solid organ transplant (SOT; heart, kidney, or liver) patients in Europe. We collected electronic data on the transplant population and prevention guidelines/regulations and clinical data on toxoplasmosis cases diagnosed during 2010-2014. Serologic pretransplant screening of allo-hematopoietic stem cell donors was performed in 80% of countries, screening of organ donors in 100%. SOT recipients were systematically screened in 6 countries. Targeted anti-Toxoplasma chemoprophylaxis was heterogeneous. A total of 87 toxoplasmosis cases were recorded (58 allo-HSCTs, 29 SOTs). The 6-month survival rate was lower among Toxoplasma-seropositive recipients and among allo-hematopoietic stem cell and liver recipients. Chemoprophylaxis improved outcomes for SOT recipients. Toxoplasmosis remains associated with high mortality rates among transplant recipients. Guidelines are urgently needed to standardize prophylactic regimens and optimize patient management.tr_TR
dc.description.indexPubmed
dc.identifier.endpage1504tr_TR
dc.identifier.issue8tr_TR
dc.identifier.startpage1497tr_TR
dc.identifier.urihttps://doi.org/10.3201/eid2408.180045tr_TR
dc.identifier.urihttp://hdl.handle.net/20.500.12575/72559
dc.identifier.volume24tr_TR
dc.language.isoentr_TR
dc.relation.isversionof10.3201/eid2408.180045tr_TR
dc.relation.journalEmerg Infect Dis .tr_TR
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıtr_TR
dc.subjectEuropetr_TR
dc.subjectToxoplasmatr_TR
dc.subjectcerebral toxoplasmosistr_TR
dc.titleToxoplasmosis in Transplant Recipients, Europe, 2010–2014tr_TR
dc.typeArticletr_TR

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