Effects of medetomidine/ketamine and xylazine/ketamine anesthesia and their reversal by atipamezole on ocular parameters and monitored anesthesia care in cats

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dc.contributor.authorKibar, Murat
dc.contributor.departmentOthertr_TR
dc.contributor.facultyOthertr_TR
dc.date.accessioned2022-12-14T13:31:06Z
dc.date.available2022-12-14T13:31:06Z
dc.date.issued2022
dc.description.abstractThe aim of this study was to investigate the impact of the general anesthetic drug ketamine and premedication agents medetomidine and xylazine, and their reversal by atipamezole, on monitored anesthesia care values and ocular parameters such as intraocular pressure, horizontal pupillar diameter, and Schirmer tear test in cats. A randomized, single-blinded study was conducted. Twenty intact female cats (weiging between 2.2 and 3.6 kg, and 0.5 to 5.5 years of age) referred for ovariohysterectomy (OHE) procedure by the owners at regular intervals over 4 months were included in the study. The cats were randomly divided into two groups containing 10 animals in each group. The cats were premedicated with medetomidine 80 µg/kg intramuscular in group 1 while the cats in the 2nd group were premedicated with xylazine hydrochloride 2 mg/kg intramuscular. After the OHE procedure was ended, anesthesia regimes were reversed by using atipamezole 200 µg/kg intramuscularly. Monitoring of respiration rate, heart rate, mean arterial pressure, peripheral arterial oxygen saturation, and body temperature were conducted using a patient monitor at T0, T1, T2, T3, and T4 time points. Both groups showed declines in intraocular pressure and increases in horizontal pupil diameter after anesthesia induction (T0 vs. T1, all, P<0.05); however, the chancing and recovery pattern of intraocular pressure and horizontal pupil diameter showed intergroup difference. In conclusion, xylazine/ketamine is more effective than medetomidine/ketamine in attenuating the intraocular pressure, increasing the horizontal pupil diameter, and alteration the monitored anesthesia care response in the general anesthesia.tr_TR
dc.description.indexTrdizintr_TR
dc.identifier.urihttps://doi.org/10.33988/auvfd.869204tr_TR
dc.identifier.urihttp://hdl.handle.net/20.500.12575/86110
dc.language.isotrtr_TR
dc.publisherAnkara Üniversitesi Veteriner Fakültesitr_TR
dc.relation.isversionof10.33988/auvfd.869204tr_TR
dc.relation.journalAnkara Üniversitesi Veteriner Fakültesi Dergisitr_TR
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Başka Kurum Yazarıtr_TR
dc.subjectAnesthesiatr_TR
dc.subjectAtipamezoletr_TR
dc.subjectoculartr_TR
dc.titleEffects of medetomidine/ketamine and xylazine/ketamine anesthesia and their reversal by atipamezole on ocular parameters and monitored anesthesia care in catstr_TR
dc.typeArticletr_TR

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