Pharmacological Applications of Nrf2 Inhibitors as Potential Antineoplastic Drugs

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dc.contributor.authorSüzen, Sibel
dc.contributor.departmentEczacılık Fakültesitr_TR
dc.contributor.otherAkillilar,Pelin Telkoparan
dc.contributor.otherLuciano, Saso
dc.date.accessioned2020-03-17T13:45:52Z
dc.date.available2020-03-17T13:45:52Z
dc.date.issued2019
dc.description.abstractOxidative stress (OS) is associated with many diseases ranging from cancer to neurodegenerative disorders. Nuclear factor-erythroid 2 p45-related factor 2 (Nrf2) is one of the most effective cytoprotective controller against OS. Modulation of Nrf2 pathway constitutes a remarkable strategy in the antineoplastic treatments. A big number of Nrf2-antioxidant response element activators have been screened for use as chemo-preventive drugs in OS associated diseases like cancer even though activation of Nrf2 happens in a variety of cancers. Research proved that hyperactivation of the Nrf2 pathway produces a situation that helps the survival of normal as well as malignant cells, protecting them against OS, anticancer drugs, and radiotherapy. In this review, the modulation of the Nrf2 pathway, anticancer activity and challenges associated with the development of an Nrf2-based anti-cancer treatment approaches are discussed.tr_TR
dc.description.indexPubmed
dc.identifier.endpage18tr_TR
dc.identifier.issn/e-issn1422-0067
dc.identifier.issue2025tr_TR
dc.identifier.startpage1tr_TR
dc.identifier.urihttps://doi.org/10.3390/ijms20082025tr_TR
dc.identifier.urihttp://hdl.handle.net/20.500.12575/70710
dc.identifier.volume20tr_TR
dc.language.isoentr_TR
dc.relation.isversionof10.3390/ijms20082025tr_TR
dc.relation.journal International Journal of Molecular Sciencestr_TR
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıtr_TR
dc.subjectNrf2 inhibitors;tr_TR
dc.subjectantineoplastic drugs;tr_TR
dc.subjectcancertr_TR
dc.subjectchemoresistance;tr_TR
dc.subjectcancer chemopreventiontr_TR
dc.subjecttherapytr_TR
dc.titlePharmacological Applications of Nrf2 Inhibitors as Potential Antineoplastic Drugstr_TR
dc.typeArticletr_TR

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