Dose-, treatment- and time-dependent toxicity of superparamagnetic iron oxide nanoparticles on primary rat hepatocytes
| dc.contributor.author | Bestepe, Furkan | |
| dc.contributor.department | Tıp Fakültesi | tr_TR |
| dc.date.accessioned | 2020-12-21T11:19:19Z | |
| dc.date.available | 2020-12-21T11:19:19Z | |
| dc.date.issued | 2018 | |
| dc.description.abstract | Aim: As a first study in literature, to investigate concentration-dependent (0-400 μg/ml) and exposure-dependent (single dosing vs cumulative dosing) effects of superparamagnetic iron oxide nanoparticles (d = 10 nm) on primary rat hepatocytes in a time-dependent manner. Materials & methods: Sandwich-cultured hepatocyte model was used to evaluate viability, hepatocyte specific functions and reactive oxygen species level. Results: In terms of all parameters, generally statistically more significant effects were observed in a concentration- and time-dependent manner. In terms of hepatocyte-specific functions, cumulative dosing caused significantly (p < 0.05) more deleterious effects at 48th hour. Conclusion: A combination of various biomarkers should be employed for the evaluation of the effect of superparamagnetic iron oxide nanoparticles on liver, and each biomarker should be analyzed in a time- and exposure-dependent manner. | tr_TR |
| dc.description.index | Pubmed | |
| dc.identifier.endpage | 1284 | tr_TR |
| dc.identifier.issue | 11 | tr_TR |
| dc.identifier.startpage | 1267 | tr_TR |
| dc.identifier.uri | https://doi.org/10.2217/nnm-2017-0387 | tr_TR |
| dc.identifier.uri | http://hdl.handle.net/20.500.12575/72578 | |
| dc.identifier.volume | 13 | tr_TR |
| dc.language.iso | en | tr_TR |
| dc.relation.isversionof | 10.2217/nnm-2017-0387 | tr_TR |
| dc.relation.journal | Nanomedicine (Lond) . | tr_TR |
| dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | tr_TR |
| dc.subject | albumin | tr_TR |
| dc.subject | primary rat hepatocytes | tr_TR |
| dc.subject | reactive oxygen species (ROS) | tr_TR |
| dc.title | Dose-, treatment- and time-dependent toxicity of superparamagnetic iron oxide nanoparticles on primary rat hepatocytes | tr_TR |
| dc.type | Article | tr_TR |