Protection of specific maternal messenger RNAs by the P body protein CGH-1 (Dhh1/RCK) during Caenorhabditis elegans oogenesis

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dc.contributor.authorAtalay, Arzu
dc.contributor.departmentBiyoteknoloji Enstitüsütr_TR
dc.contributor.otherBoag, Peter R.
dc.contributor.otherRobida, Stacey I.
dc.date.accessioned2020-05-27T12:38:16Z
dc.date.available2020-05-27T12:38:16Z
dc.date.issued2008
dc.description.abstractDuring oogenesis, numerous messenger RNAs (mRNAs) are maintained in a translationally silenced state. In eukaryotic cells, various translation inhibition and mRNA degradation mechanisms congregate in cytoplasmic processing bodies (P bodies). The P body protein Dhh1 inhibits translation and promotes decapping-mediated mRNA decay together with Pat1 in yeast, and has been implicated in mRNA storage in metazoan oocytes. Here, we have investigated in Caenorhabditis elegans whether Dhh1 and Pat1 generally function together, and how they influence mRNA sequestration during oogenesis. We show that in somatic tissues, the Dhh1 orthologue (CGH-1) forms Pat1 (patr-1)-dependent P bodies that are involved in mRNA decapping. In contrast, during oogenesis, CGH-1 forms patr-1-independent mRNA storage bodies. CGH-1 then associates with translational regulators and a specific set of maternal mRNAs, and prevents those mRNAs from being degraded. Our results identify somatic and germ cell CGH-1 functions that are distinguished by the involvement of PATR-1, and reveal that during oogenesis, numerous translationally regulated mRNAs are specifically protected by a CGH-1-dependent mechanism. © 2008 Boag et al.tr_TR
dc.identifier.endpage557tr_TR
dc.identifier.issue3tr_TR
dc.identifier.startpage543tr_TR
dc.identifier.urihttps://doi.org/10.1083/jcb.200801183tr_TR
dc.identifier.urihttp://hdl.handle.net/20.500.12575/71252
dc.identifier.volume182tr_TR
dc.language.isoentr_TR
dc.relation.isversionof10.1083/jcb.200801183tr_TR
dc.relation.journalJournal of Cell Biologytr_TR
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıtr_TR
dc.subjectRNAtr_TR
dc.subjectRNA Stabilitytr_TR
dc.subjectSG assemblytr_TR
dc.titleProtection of specific maternal messenger RNAs by the P body protein CGH-1 (Dhh1/RCK) during Caenorhabditis elegans oogenesistr_TR
dc.typeArticletr_TR

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