Böbrek nakli alıcılarında erken ve geç dönem graft fonksiyonu üzerine etkili faktörlerin değerlendirilmesi
Chronic kidney disease is an important public heath issue. End stage renal disease needs to be treated with renal replacement therapies. Considering the quality of life and patient survival renal transplantation is the best therapy approach. Methods: We retrospectively analysed records of 343 transplant patients, grafted between January 2002 and October 2013 at Renal Transplantation Unit of Ankara University School of Medicine. Date of transplant, patients and donors demographic properties, donor type, immunologic and nonimmunologic properties, posttransplantation graft status and complication datas were collected, if happened graft and patient loss were examined with their reason. Results: Most of the transplants (%79.0) were from living donors. One and five year graft survival rates were %94.4, %92.3 for deceased donor transplants; %98.1, %92.7 for living donor transplants (p=0.834); overall patient survival rates were %97.2, %89.9 and %99.3, %98.7, respectively (p=0.004). We demonstrated renal transplantation history, longer dialysis vintage, high creatinine value at discharge, recurrence of native kidney disease, acute rejection, chronic renal allograft dysfunction were associated with poor graft survival. We evaluated these factors by Cox regression analysis, renal transplantation history, longer dialysis vintage lost their significance. Recipient age over 46 years, dialysis vintage ≥ 55 months and cardiovascular morbidities were independently associated with patient loss. Conclusion: In this study, we demonstrated the risk factors affecting graft and patient survival in our renal transplant patients. These datas is useful and important for selection of patient, selection of donor, and posttransplant monitoring of the recipient.