Behçet hastalarında, JAK2,STAT 3 gen polimorfizmlerinin incelenmesi

Abstract

Behçet's disease (BD) is a multisystem inflammatory disorder characterized by recurrent oral and genital ulcers and ocular inflammation, pulmonary and neurologic involvement. Although the aetiology and pathogenesis is not clearly defined, genetic predisposition (HLA-B51), infections and immunological dysfunctions have been implicated. BD is most prevalent along the Silk Road. In recent years, Genomw-wide association study (GWAS) identified several genes associated with the disease and role of non-MHC gens in BH patogenesis has been saggested. In this study we investigated two gens, STAT 3, JAK 2, that probably play a pathogenic roles in BH and the functions associated with BH susceptibility, by GWAS study, gens investigated the relationship with BH by case-control genotyping study. Behcet's disease is well known all over the world. Our study included a total 200 patients and 100 healthy control whether, rs10974944 in JAK 2, rs2293152 in STAT3 polymorphisms were investigated by PCR-RFLP methodes. We observed that in this disease the rs10974944 in JAK 2 gene (C / G) polymorphism of the C allele of the examined patients and healthy controls were homozygous or heterozygous can bring in terms of susceptibility to carry an increased risk of Behcet's disease.