Yeni nesil nanosensör tasarımı ve antiparkinson ilaç analizlerinde kullanımı
Özet
In this dissertation electrochemical studies are performed for ropinirole, pramipexole and piribedil, which are used for the treatment of the Parkinson's disease. Non-modified electrodes and nanosensors are used for the studies of ropinirole and pramipexole and non-modified BDDE is used for the studies of piribedil. The oxidation behaviours of these drugs are analyzed with different supporting electrolytes between pH 0,3 – 12,0 by using CV, DPV, SWV and stripping techniques. The transfer mechanism of the drug to the electrode surface and electron numbers are attempted to be calculated through separate scan rate studies with CV technique under the optimum conditions and the mechanisms are tried to be enlightened. The parameters are optimized in accordance with the method developed for each drug at the most analytically appropriate media, the calibration curves are drawn and the required validation parameters are studied. AdSDPV and AdSSWV techniques are successfully used because of facilitation of adsorption of the drugs through nanoparticles. Therefore, for ropinirole and pramipexole, limit of detection values corresponding to the concentrations of 10-10 – 10-9 M are obtained, which shows that the developed methods are very sensitive. Since, a stable and reproducable nanosensor can not be developed for piribedil, the analysis is made with BDDE and limit of detection values corresponding to the concentration of 10-8 M is obtained. The applicability of developed techniques and nanosensors are shown through analyzing from pharmaceutical dosage forms as well.