Ankara bölgesinde yaşayan Ankara Üniversitesi Tıp Fakültesi Hastanesi Dahiliywe Polikliniklerine başvuran postmenopozal osteoporozlu kadınlarda D vitamini eksikliği görülme oranı
Özet
Vitamin D, being one of the major elements of osteoporosis treatment, isinvolved in the calcium metabolism of the body. Vitamin D deficiency causesosteoporosis, osteopenia and osteomalacia.In studies conducted all over the world, it has been reported thatpostmenopausal women with osteoporosis have various degrees of vitamin Ddeficiency; vitamin levels varying according to age, geographical latitude, seasons,the amount taken in through the diet.In this study that we conducted to define the frequency of vitamin D deficiencyin postmenopausal women, 131 were observed and in conformity with the diagnosticcriteria of the World Health Organization, they were scanned with Dexa to be dividedinto 3 groups;namely osteoporosis, osteopenia, and the control group. Duringmedical visits, patients' clothing habits, and daily sunlight exposure rates have beenscored from 1 to 4. Vitamin D, PTH, osteocalcin, DPD, calcium, phosphorus, ALPlevels of the groups were compared.29.8 % of the women had osteoporosis, and 45.8 % had osteopenia. 48 women(36.6 %) were reported to have severe vitamin D deficiency (25-OH-D<10ng/ml), 38women (%29) moderate vitamin D deficiency (10?25-OH-D<20 ng/ml), and 22women (%16,8) mild vitamin D deficiency (20?25-OH-D<30 ng/ml). Only 17.6 %of the women were reported to have vitamin D levels higher than 30 ng/ml. It wasalso observed that the higher the clothing habits score(or in other words, the greaterthe area of skin covered by clothing), the lower vitamin D levels. Since the numberof cases was insufficient, it was not possible to determine the impact of sun exposureto vitamin D levels.It was observed that as the vitamin D levels dropped, PTH levels increased. Thethreshold 25-OH-D level under which secondary hyperparathyroidism occurs wasestimated as 16,3 ng/ml. If this threshold level is accepted to denote vitamin Ddeficiency, the fraction of vitamin D deficient women amounts to the 54,9% of oursample of postmenopausal women.When the relation between the bone markers and vitamin D was examined, anegative relation was observed between vitamin D and osteocalcin and a positiverelation was observed between ALP, osteocalcin and PTH.There are countries associated with vitamin D deficiency from anepidemiological point of view. Since the research to find out preventive effects ofvitamin D on chronic diseases such as cancer, hypertension, diabetes mellitus areunderway; and since it is already known that vitamin D reduces the risk of falls andfracture, further epidemiological studies concerning vitamin D should be done also inTurkey. Depending on the results, it may be concluded that nutrients such as milkshould be enriched with vitamin D