N-sübstitüe indol-2-karboksilik asit türevlerinin sentezi, antispazmodik ve analjezik etkilerinin araştırılması
VIII. SUMMARY In many countries, different compounds are used in the same drug combination for their analgesic and antispasmodic activities. But in the recent years, in different countries including Turkey, most of the licenced of such drugs are being canceled, because of unexpected and severe side effects of their active ingredients which are appeared particularly when they are in the same combination. In addition to this, there are also some difficulties for analitical control of those drugs when they include more than one active compound. For these reasons, in our thesis we have aimed to design and synthesis of N- substituted-indol-2-carboxylic acid derivatives, which would exhibite both analgesic and antispasmodic activities in the same compound The investigation of their pharmacological activities was also targeted to be done in the thesis' study. In the synthesis part of our study, we have completed the synthesis of 23 compounds in three different series. Those are; 1-N-benzyl derivatives 2-N-phenyl derivatives 3-N-H derivatives The structural elucidation of entire compounds were convinced by ITK, melting point and elementary analysis and UV, IR, 1H-NMR, Mass spectroscopies were also used for this reason. In order to search the pharmacological activities of synthetised compounds, the MAGNUS Method was performed for the antispasmodic activity by using guinea-pig ileum and the compounds were compared with Atropin. The tested compounds (S2, S2a,S2b ) were found promising for antispasmodic activity and they were also chosen for analgesic activity test. The results of analgesic activity tests, which was performed by VVRİTHİNG Method, indicate that; the compounds with no substituents at the first position of indole ring (Si, S2) have better activity than the other series of compounds (S2a, Sa2,S2b,Sb2), when they were 153compared with Indomethacin. It was also determined that, the methyl halogenür salts of synthetised compouds were less active than the HCI salts. For the last word, it can be said that ; the synthesised compouds are important and promising for the future with their analgesic and antispasmodic activities. Keywords Indole, Antispasmodic, Analgesic, Acetylcholine, Spectrum, Indomethacin.