Medüller dışı differansiye tiroid karsinomu olan bireylerin yakın akrabalarında tiroid hastalıkları ve tiroid kanseri sıklığı

Abstract

Introduction and Objective: Incidence of thyroid carcinoma is gradually increasing, and differantiated thyroid carcinomas account for 95% of thyroid cancers. Although most NMTC are sporadic, it has been reported to be 3,5-6,2% familial in different studies. Thyroid nodules are the most common diseases of thyroid gland. Hashimoto thyroiditis markedly affects public health and is the most seen inflammatory disease of thyroid gland. The frequency of benign and malignant thyroid diseases is unknown in NMTC patients’close relatives. Material and Methods: 50 NMTC patients were enrolled to this study, 110 relatives were invited to the hospital. 79 women and 31 men were included the study. After the risk assesment and physical examination, volunteers gave blood sample for thyroid function tests and thyroid antibodies (anti-TPO, anti-tg). Then ultrasonography was performed and biopsy was taken if necessary. Written informed consent was obtained from all patients. Results: 110 volunteers were enrolled to this study, 79 were women (71,8%) and 31 were men (28,2%). The average age was 38,4 (18-58). Thyroid function tests were in normal range. Anti-TPO was positive in 24 volunteers (21.8%) and anti-tg in 6 volunteers (5.4%). Thyroid ultrasonography revealed diffuse thyroid parenchyma in 37 patients, while mild thyroiditis was detected in 61 patients and moderate thyroiditis in 12 patients (33.6%, 55.4%, 11%, respectively). Pseudonodular appearance was detected in 6 volunteers on ultrasonography. A total of 57 thyroid nodules were seen in 23 (20.9%) of the volunteers and we performed fine needle aspiration biopsy for 12 nodules. Pathologic examination was resulted as benign in all nodules. Conclusion:The current study is a screening study. The frequency of thyroid nodules was found to be consistent with previous sonographic community studies’ results. Although the rate of chronic autoimmune thyroiditis was found to be high, none of the volunteers had hypothyroidism. Chronic autoimmune thyroiditis was significantly higher in women as expected