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dc.contributor.authorŞeker, Şükran
dc.date.accessioned2020-11-20T08:09:19Z
dc.date.available2020-11-20T08:09:19Z
dc.date.issued2018
dc.identifier.urihttps://doi.org/10.3906/biy-1802-97tr_TR
dc.identifier.urihttp://hdl.handle.net/20.500.12575/72494
dc.description.abstractIn this study, the possible cellular effects of tin dioxide (SnO2) nanoparticles, together with its bulk form, on mouse dermal fibroblasts (DFs) were revealed using in vitro assays. Particle characterizations were carried out with AFM, Braun-Emmet-Teller, and DLS analyses. The cells were treated with nano and bulk SnO2 at concentrations of 0.1, 1, 10, 50, and 100 μg/mL for 6, 24, and 48 h. At the end of the exposure periods, the morphology, viability, particle uptake, and membrane leakage statuses of the cells were evaluated. Furthermore, real-time monitoring of cell responses was performed by using an impedance-based label-free system. Findings showed that at concentrations of 0.1-10 μg/mL, cells had similar doubling time to that of control cells (20.4 ± 2.6 h), while the doubling time of cells exposed to 100 μg/mL of nano and bulk SnO2 increased slightly (P ˃ 0.05) to 25.1 ± 3.9 h and 26.2 ± 5.9 h, respectively. The results indicated that DFs exhibited a similar toxicity response to nano and bulk SnO2; thus, 50 and 100 μg/mL of nano and bulk SnO2 had mild toxic effects on DFs. In conclusion, this study provides information and insight necessary for the safe use of SnO2 in medical and consumer products.tr_TR
dc.language.isoentr_TR
dc.relation.isversionof10.3906/biy-1802-97tr_TR
dc.subjectMTTtr_TR
dc.subjectTin oxide nanoparticlestr_TR
dc.subjectcell indextr_TR
dc.titleComparative evaluation of nano and bulk tin dioxide cytotoxicity on dermal fibroblasts by real-time impedance-based and conventional methodstr_TR
dc.typeArticletr_TR
dc.relation.journalTurk J Biol .tr_TR
dc.contributor.departmentFen Fakültesitr_TR
dc.identifier.volume42tr_TR
dc.identifier.issue5tr_TR
dc.identifier.startpage435tr_TR
dc.identifier.endpage446tr_TR
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıtr_TR


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