dc.contributor.author | İnce, Elif | |
dc.date.accessioned | 2020-05-29T07:21:40Z | |
dc.date.available | 2020-05-29T07:21:40Z | |
dc.date.issued | 2006-07-15 | |
dc.identifier.uri | https://doi.org/10.1016/j.bbmt.2006.07.006 | tr_TR |
dc.identifier.uri | http://hdl.handle.net/20.500.12575/71259 | |
dc.description.abstract | Hematopoietic stem cell transplantation (HSCT) is being used to treat a wide spectrum of clinical disorders
but opportunistic infection remains an important factor determining outcomes for these patients. Nontuberculous mycobacterial (NTM) infections are being reported more frequently in HSCT recipients and the
incidence of NTM infections in adult recipients is reported to be 0.4%-4.9%. However, the incidence and
severity of NTM infections are less well described in pediatric HSCT recipients. Centers for Disease Control
and Prevention guidelines were used to define definite and probable NTM infection among 132 children
undergoing 169 HSCT between January 2000 and December 2004 at our institution. NTM infection was
diagnosed in 5 of 132 pediatric recipients (3.8%). There were no NTM infections diagnosed in the autologous
HSCT recipients and the incidence of NTM in allogeneic HSCT recipients was 6.4% (95% confidence interval,
0.8-11.9). The mean age of the HSCT recipients who developed NTM infections was 8 years (range, 2-19
years); 3 were male and 2 were female. Four conditioning regimens included alemtuzumab and 3 had
antithymocyte globulin. Of the 5 patients with NTM infections, 2 met the criteria for definite infection and
3 for probable infection. Of the 2 patients with definite NTM infection, 1 had disseminated disease with
Mycobacterium avium complex and the other had Mycobacterium chelonae catheter-related bloodstream
infection. The probable NTM infections were 1 skin infection with Mycobacterium kansasii and 2 lower
respiratory tract infections with M avium complex. Median time to NTM infection was 115 days (range,
14-269 days) after HSCT. Two patients had graft-versus-host disease at the time of NTM infection. All
5 patients received 3-4 antimycobacterial drugs and all NTM infections resolved. In summary, the
incidence of NTM infection in pediatric HSCT recipients appears similar to that described in adult HSCT
recipients and the outcome appears to be excellent with the proper antibiotic therapy. The increased use
of anti-T cell antibodies appears to be associated with an increased risk of NTM infections in pediatric
HSCT recipients. Multicenter studies are needed to identify the risk factors, early diagnostic criteria, and
optimal therapy. | tr_TR |
dc.language.iso | en_US | tr_TR |
dc.relation.isversionof | 10.1016/j.bbmt.2006.07.006 | tr_TR |
dc.subject | Atypical mycobacteria | tr_TR |
dc.subject | Nontuberculous mycobacteria | tr_TR |
dc.subject | Transplant | tr_TR |
dc.subject | Pediatric | tr_TR |
dc.subject | Alemtuzumab | tr_TR |
dc.title | A Low Incidence of Nontuberculous Mycobacterial Infections in Pediatric Hematopoietic Stem Cell Transplantation Recipients. | tr_TR |
dc.type | Article | tr_TR |
dc.relation.journal | Biology of Blood and Marrow Transplantation | tr_TR |
dc.contributor.department | Tıp Fakültesi | tr_TR |
dc.identifier.volume | 12 | tr_TR |
dc.identifier.issue | 01 | tr_TR |
dc.identifier.startpage | 1188 | tr_TR |
dc.identifier.endpage | 1197 | tr_TR |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | tr_TR |