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dc.contributor.authorDedeoğlu, Bala Gür
dc.contributor.otherIslakoğlu, Yasemin Öztemur
dc.contributor.otherNoyan, Senem
dc.date.accessioned2020-05-08T12:30:04Z
dc.date.available2020-05-08T12:30:04Z
dc.date.issued2018
dc.identifier.urihttps://doi.org/10.3906/biy-1708-17tr_TR
dc.identifier.urihttp://hdl.handle.net/20.500.12575/71233
dc.description.abstractBreast cancer is the most common cancer among women and the molecular pathways that play main roles in breast cancer regulation are still not completely understood. MicroRNAs (miRNAs) and transcription factors (TFs) are important regulators of gene expression. It is important to unravel the relation of TFs, miRNAs, and their targets within regulatory networks to clarify the processes that cause breast cancer and the progression of it. In this study, mRNA and miRNA expression studies including breast tumors and normal samples were extracted from the GEO microarray database. Two independent mRNA studies and a miRNA study were selected and reanalyzed. Differentially expressed (DE) mRNAs and miRNAs between breast tumor and normal samples were listed by using BRBArray Tools. CircuitsDB2 analysis conducted with DE miRNAs and mRNAs resulted in 3 significant circuits that are SOX10- and hsamiR- 301a-dependent. The following significant circuits were characterized and validated bioinformatically by using web-based tools: SOX10→hsa-miR-301a→HOXA3, SOX10→hsa-miR-301a→KIT, and SOX10→hsa-miR-301a→NFIB. It can be concluded that regulatory motifs involving miRNAs and TFs may be useful for understanding breast cancer regulation and for predicting new biomarkers. © TÜBİTAKtr_TR
dc.language.isoentr_TR
dc.relation.isversionof10.3906/biy-1708-17tr_TR
dc.subjectBreast cancertr_TR
dc.subjectMiRNAtr_TR
dc.subjectmRNAtr_TR
dc.subjectRegulatory circuitstr_TR
dc.subjectTranscription factortr_TR
dc.titleHsa-miR-301a- and SOX10-dependent miRNA-TF-mRNA regulatory circuits in breast cancertr_TR
dc.typeArticletr_TR
dc.relation.journalTurkish Journal of Biologytr_TR
dc.contributor.departmentBiyoteknoloji Enstitüsütr_TR
dc.identifier.volume42tr_TR
dc.identifier.issue2tr_TR
dc.identifier.startpage103tr_TR
dc.identifier.endpage112tr_TR
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıtr_TR


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