Basit öğe kaydını göster

dc.contributor.authorYılmaz, Erkan
dc.contributor.otherKarabiyik, Afife
dc.contributor.otherGüleç, Şükrü
dc.contributor.otherCelalettin Haznedaroǧlu, Ibrahim
dc.contributor.otherAkar, Nejat
dc.date.accessioned2020-05-08T12:29:55Z
dc.date.available2020-05-08T12:29:55Z
dc.date.issued2011
dc.identifier.urihttps://doi.org/10.1177/1076029610394437tr_TR
dc.identifier.urihttp://hdl.handle.net/20.500.12575/71230
dc.description.abstractAnkaferd Blood Stopper (ABS) is a novel topical hemostatic agent with pleiotropic actions indicated in clinical hemorrhages. Protease-activated receptor 1 (PAR-1) is located in the crossroads of hemostasis, inflammation, infection, apoptosis and tumorigenesis. ABS-induced formation of the protein network with vital erythroid aggregation covers the entire physiological hemostatic process. The aim of this study is to assess the effects of ABS on PAR-1 in the Human Umbilical Vein Endothelial Cells (HUVEC) model, in relation to the "ipopolysaccharides (LPS)-challenge" to endothelium. For this purpose, ABS 10 μL and 100 μL, had been applied to HUVEC within the time periods of 5 minutes (min), 25 min, 50 min, 6 hours (h) and 24 h. The cells have lifted from the plastic surface and adhered to each other during theABSapplication to the HUVECs. After 24 hours the cells returned to normal baseline level. We observed dose-dependent reversible PAR-1 down-regulation mediated by ABS inside the human umbilical vein endothelial cells. ABS-induced sustained PAR-1 down-regulation in the presence of LPS. Those findings indicated that ABS hemostatic agent may act as a topical biological response modifier by acting on PAR-1 at the vascular endothelial and cellular level.tr_TR
dc.language.isoentr_TR
dc.relation.isversionof10.1177/1076029610394437tr_TR
dc.subjectAnkaferd Blood Stopper (ABS)tr_TR
dc.subjectHemostasistr_TR
dc.subjectHuman umbilical vein endothelial cells (HUVEC)tr_TR
dc.subjectprotease-activated receptor 1tr_TR
dc.subjectThrombosistr_TR
dc.titleReversible protease-activated receptor 1 downregulation mediated by ankaferd blood stopper inducible with lipopolysaccharides inside the human umbilical vein endothelial cellstr_TR
dc.typeArticletr_TR
dc.relation.journalClinical and Applied Thrombosis/Hemostasistr_TR
dc.contributor.departmentBiyoteknoloji Enstitüsütr_TR
dc.contributor.authorIDhttp://orcid.org/0000-0001-7355-3878tr_TR
dc.identifier.volume17tr_TR
dc.identifier.issue6tr_TR
dc.identifier.startpage165tr_TR
dc.identifier.endpage170tr_TR
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıtr_TR


Bu öğenin dosyaları:

Bu öğe aşağıdaki koleksiyon(lar)da görünmektedir.

Basit öğe kaydını göster