The molecular mechanisms of the effect of anticancer activity on lichen metabolites
Duman, Demet Cansaran
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The components obtained from natural products have been used in many fields such as medicine, pharmacy and biology throughout the history. Some important new commercial drugs have been obtained from natural molecule using as a model in the cancer field. Studies for the development of cytotoxic agents were an important step for the discovery of new anticancer drugs. Large structural diversity of natural components and their bioactivity potential may serve to improve the therapeutic potential with molecular modification. The number of studies on the anticancer activity of lichen components has increased in last few years. Lichens are symbiotic organisms of fungus and algae or cyanobacteria. Lichens synthesize a great variety of secondary metabolites. Lichen secondary compounds have many possible biological activities such as antiviral, antitumor, antibacterial and antiherbivore and antioxidants. In recent years, one of the most important features of lichen secondary metabolites will also be candidate molecules in the treatment of anticancer therapy in the medical and biotechnology studies. Elucidation of the molecular basis of cancer related processes and also apoptosis pathway are provide to great utility in finding alternative drugs for treating cancer. In this review research the knowledge about lichen secondary metabolites, the potential for effective use in the treatment of cancer, all molecular mechanisms in cancerous processes and mainly apoptosis pathway.