Formulation and detailed characterization of voriconazole loaded in situ gels for ocular application
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Tarih
2020Yazar
Okur, Neslihan Üstündağ
Yozgatlı, Vildan
Şenyiğit, Zeynep
Üst veri
Tüm öğe kaydını gösterÖzet
Objective: This study was aimed to prepare, characterize and evaluate in situ gel formulation for a
sustained ocular delivery of voriconazole.
Material and Method: In situ gels were prepared with three different hydrophilic co-polymers:
Poloxamer 188, 407 and 388. The formulations were characterized in terms of their clarity, pH, viscosity
drug content uniformity and mechanical/rheological properties. Moreover, in vitro drug release and
stabilitystudies were performed.
Result and Discussion: The results showed that the optimized in situ gel formulation had desired in vitro
properties and a good stability over the period of 3 months. Texture profile analysis presented that
formulations offered suitable adhesive and mechanical properties. P2-V formulation exhibited pseudoplastic flow and typical gel-type mechanical spectra (G′ > G″) at different frequecy values and at different
temperatures. Moreover, all formulations showed a sustained drug release for 24 hours. In conclusion,
voriconazole loaded in situ gel could be offered as an encouraging strategy as ocular systems for ocular
infections treatment.