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dc.contributor.authorKansu Tanca, Aydan
dc.contributor.otherKuloğlu, Z
dc.date.accessioned2020-04-03T08:18:48Z
dc.date.available2020-04-03T08:18:48Z
dc.date.issued2006-01
dc.identifier.urihttp://hdl.handle.net/20.500.12575/70894
dc.description.abstractThe clinical outcome of nonobstructive neonatal cholestasis (NC) cases varies greatly and the prognosis is generally unpredictable. In this study, we aimed to evaluate the prognostic benefits of qualitative analysis of histopathological changes in nonobstructive NC cases. A total of 28 nonobstructive NC cases (18 neonatal hepatitis; 10 intrahepatic bile duct paucity) were studied. We analyzed the relationship between histopathological and clinical parameters. Hepatic inflammation, bridging necrosis, pericellular fibrosis, giant cell transformation, and extramedullary hematopoiesis were evaluated and scored according to their absence or presence in each case. The sum of the histopathological scores was accepted as ‘‘total pathological injury score.’’ The height percentiles, the presence and the degree of hepatomegaly and ascites, and serum alanine aminotransferase (ALT), albumin, and bilirubin levels and prothrombin time were also evaluated and scored. The patients were divided into 2 clinical course groups considered ‘‘good’’ or ‘‘bad’’ according to the total clinical scores. For statistical analysis, Pearson’s chi-square test, Mann-Whitney U-test, and receiver operating characteristic curve were used. We found a statistically significant negative relation between the clinical course and total pathological injury score (P ¼ 0.042) and pericellular fibrosis (P ¼ 0.016). In conclusion, during the interpretation of liver biopsies of nonobstructive NC, scoring of histopathological changes should be done for assessing the clinical prognostic outcome.tr_TR
dc.language.isoentr_TR
dc.subjectneonatal cholestasis, prognosis, histopathological changes, scoringtr_TR
dc.titleNonobstructive neonatal cholestasis: clinical outcome and scoring of the histopathological changes in liver biopsies.tr_TR
dc.typeArticletr_TR
dc.relation.journalPediatr Dev Patholtr_TR
dc.contributor.departmentTıp Fakültesitr_TR
dc.identifier.volume9tr_TR
dc.identifier.issue1tr_TR
dc.identifier.startpage44tr_TR
dc.identifier.endpage51tr_TR
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıtr_TR


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