dc.description.abstract | The clinical outcome of nonobstructive neonatal cholestasis (NC) cases varies greatly and the prognosis is
generally unpredictable. In this study, we aimed to
evaluate the prognostic benefits of qualitative analysis of
histopathological changes in nonobstructive NC cases. A
total of 28 nonobstructive NC cases (18 neonatal hepatitis;
10 intrahepatic bile duct paucity) were studied. We
analyzed the relationship between histopathological and
clinical parameters. Hepatic inflammation, bridging necrosis, pericellular fibrosis, giant cell transformation, and
extramedullary hematopoiesis were evaluated and scored
according to their absence or presence in each case. The
sum of the histopathological scores was accepted as ‘‘total
pathological injury score.’’ The height percentiles, the
presence and the degree of hepatomegaly and ascites, and
serum alanine aminotransferase (ALT), albumin, and
bilirubin levels and prothrombin time were also evaluated
and scored. The patients were divided into 2 clinical
course groups considered ‘‘good’’ or ‘‘bad’’ according to
the total clinical scores. For statistical analysis, Pearson’s
chi-square test, Mann-Whitney U-test, and receiver
operating characteristic curve were used. We found a
statistically significant negative relation between the
clinical course and total pathological injury score (P ¼
0.042) and pericellular fibrosis (P ¼ 0.016). In conclusion,
during the interpretation of liver biopsies of nonobstructive NC, scoring of histopathological changes should be
done for assessing the clinical prognostic outcome. | tr_TR |