A rapid lateral flow stool antigen immunoassay and (14)C-urea breath test for the diagnosis and eradication of Helicobacter pylori infection in children.
Kansu Tanca, Aydan
MetadataShow full item record
Our aim was to evaluate diagnostic accuracy of rapid immunochromatographic stool antigen test (Rapid HpSA; LİNEAR Chemical,Barcelona, Spain) and a practical low-dose14C urea breath test (UBT) (Heliprobe™) test before and after eradication therapy. One hundrednine children with abdominal symptoms (age range, 5–17 years; mean, 12.1) underwent endoscopy,14C-UBT, and Rapid HpSA. Patientswere defined asHpinfected when histology was positive forHp. Forty children (36.6%) wereHpinfected. The sensitivity of Rapid HpSAand14C-UBT was 65% and 92.5% (P= 0.0003), respectively; the specificity of Rapid HpSA and14C-UBT was 92.3% and 85.5% (P=0.180), respectively. After eradication therapy endoscopy,14C-UBT and Rapid HpSA were repeated. The eradication rate was 70.5%. Aftereradication, the sensitivity of Rapid HpSA and14C-UBT was 60% and 100%, respectively; the specificity of Rapid HpSA and14C-UBT was100%.14C-UBT was more reliable than the Rapid HpSA test for the diagnosis and for confirming eradication ofHpinfection