dc.contributor.author | Kansu Tanca, Aydan | |
dc.date.accessioned | 2020-04-01T11:04:03Z | |
dc.date.available | 2020-04-01T11:04:03Z | |
dc.date.issued | 2017-06 | |
dc.identifier.other | 23 | tr_TR |
dc.identifier.uri | https://doi.org/10.3748/wjg.v23.i24.4437 | tr_TR |
dc.identifier.uri | http://hdl.handle.net/20.500.12575/70860 | |
dc.description.abstract | AIM
To verify the precision and accuracy of transglutaminase
antibodies (TGA) assays across Mediterranean countries.
METHODS
This study involved 8 referral centres for celiac disease
(CD) in 7 Mediterranean countries. A central laboratory
prepared 8 kits of 7 blinded and randomized serum
samples, with a titrated amount of Human TGA IgA.
Each sample was analysed three times on three
different days, with each centre running a total of 21
tests. The results were included in a blindly coded
report form, which was sent to the coordinator centre.
The coordinator estimated the mean coefficient of
Variation (CoVar = σ/μ), the mean accuracy (Accur
= Vobserved - Vreal) and the mean percent variation
(Var% = [(Vobserved - Vreal)/Vreal] × 100).
RESULTS
The analysis showed that 79.17% of the mean variation
fell between -25% and +25% of the expected value,
with the accuracy and precision progressively increasing
with higher titres of TGA. From values 1.25 times
greater than the normal cut-off, the measurements
were highly reliable.
CONCLUSION
TGA estimation is a crucial step for the diagnosis of
CD; given its accuracy and precision, clinicians could be
confident in establishing a diagnosis. | tr_TR |
dc.language.iso | en | tr_TR |
dc.relation.isversionof | 10.3748/wjg.v23.i24.4437 | tr_TR |
dc.subject | coeliac disease; gluten; transglutaminase; non-invasive testing; accuracy; precision | tr_TR |
dc.title | Variability of anti-human transglutaminase testing in celiac disease across Mediterranean countries | tr_TR |
dc.type | Article | tr_TR |
dc.relation.journal | World J Gastroenterol | tr_TR |
dc.contributor.department | Tıp Fakültesi | tr_TR |
dc.identifier.volume | 24 | tr_TR |
dc.identifier.issue | 4437 | tr_TR |
dc.identifier.startpage | 4443 | tr_TR |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Başka Kurum Yazarı | tr_TR |