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dc.contributor.authorKansu Tanca, Aydan
dc.date.accessioned2020-04-01T11:04:03Z
dc.date.available2020-04-01T11:04:03Z
dc.date.issued2017-06
dc.identifier.other23tr_TR
dc.identifier.urihttps://doi.org/10.3748/wjg.v23.i24.4437tr_TR
dc.identifier.urihttp://hdl.handle.net/20.500.12575/70860
dc.description.abstractAIM To verify the precision and accuracy of transglutaminase antibodies (TGA) assays across Mediterranean countries. METHODS This study involved 8 referral centres for celiac disease (CD) in 7 Mediterranean countries. A central laboratory prepared 8 kits of 7 blinded and randomized serum samples, with a titrated amount of Human TGA IgA. Each sample was analysed three times on three different days, with each centre running a total of 21 tests. The results were included in a blindly coded report form, which was sent to the coordinator centre. The coordinator estimated the mean coefficient of Variation (CoVar = σ/μ), the mean accuracy (Accur = Vobserved - Vreal) and the mean percent variation (Var% = [(Vobserved - Vreal)/Vreal] × 100). RESULTS The analysis showed that 79.17% of the mean variation fell between -25% and +25% of the expected value, with the accuracy and precision progressively increasing with higher titres of TGA. From values 1.25 times greater than the normal cut-off, the measurements were highly reliable. CONCLUSION TGA estimation is a crucial step for the diagnosis of CD; given its accuracy and precision, clinicians could be confident in establishing a diagnosis.tr_TR
dc.language.isoentr_TR
dc.relation.isversionof10.3748/wjg.v23.i24.4437tr_TR
dc.subjectcoeliac disease; gluten; transglutaminase; non-invasive testing; accuracy; precisiontr_TR
dc.titleVariability of anti-human transglutaminase testing in celiac disease across Mediterranean countriestr_TR
dc.typeArticletr_TR
dc.relation.journalWorld J Gastroenteroltr_TR
dc.contributor.departmentTıp Fakültesitr_TR
dc.identifier.volume24tr_TR
dc.identifier.issue4437tr_TR
dc.identifier.startpage4443tr_TR
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Başka Kurum Yazarıtr_TR


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