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dc.contributor.authorKınıklı, Gülay
dc.contributor.otherAteş, Aşkın
dc.contributor.otherTurgay, Murat
dc.contributor.otherAkay, Gülay
dc.contributor.otherKınıklı, Sami
dc.contributor.otherTokgöz, Güner
dc.date.accessioned2020-03-26T07:33:37Z
dc.date.available2020-03-26T07:33:37Z
dc.date.issued2003
dc.identifier.urihttps://doi.org/10.1080/03009740310003901tr_TR
dc.identifier.urihttp://hdl.handle.net/20.500.12575/70764
dc.description.abstractAssociation with human leukocyte antigen (HLA)-DRB alleles, implicated in the aetiopathogenesis of rheumatoid arthritis (RA), is found to be different in various ethnic groups. This study aimed to investigate DRB1 alleles in RA patients in Turkey, and to examine the effect of these alleles on disease severity. Methods: We performed PCR-based DRB1 genotyping of 104 RA patients recruited from clinical settings and 110 healthy controls. HLA DRB1 alleles frequencies in RA patients and healthy controls were determined. Phenotype frequencies of patients and controls were compared. Disease severity was assessed by radiological erosion, presence of extra-articular involvement, and functional index. Results: Significant differences were in the frequencies of DRB1*04 (46.2% versus 20.9%, p<0.001), DRB1*0401 (10.6% versus 0%, p<0.001), DRB1*0405 (8.7% versus 0%, p = 0.001), DRB1* 0404 (15.4% versus 3.6%, p<0.01), DRB1*01 (21.2% versus 10.9%, p<0.05) and DRB1* (16.3% versus 5.5%, p = 0.01) between RA patients and controls. HLA-DRB1 alleles did not show any association with seropositivity, extra-articular involvement, radiological erosion, or functional index. Conclusion: Our results suggest that the HLA-DRB1 alleles, particularly HLA-DRB1*04 and subtypes, were associated with RA.tr_TR
dc.language.isoentr_TR
dc.relation.isversionof10.1080/03009740310003901tr_TR
dc.subjectDisease susceptibilitytr_TR
dc.subjectExtra-articular involvementtr_TR
dc.subjectFunctional indextr_TR
dc.subjectHLA-DRB1tr_TR
dc.subjectRadiological erosiontr_TR
dc.subjectRheumatoid arthritistr_TR
dc.subjectSeropositivitytr_TR
dc.titleHLA-DRB1 genes and disease severity in rheumatoid arthritis in Turkeytr_TR
dc.typeArticletr_TR
dc.relation.journalScandinavian Journal of Rheumatologytr_TR
dc.contributor.departmentTıp Fakültesitr_TR
dc.identifier.volume32tr_TR
dc.identifier.issue5tr_TR
dc.identifier.startpage277tr_TR
dc.identifier.endpage280tr_TR
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıtr_TR


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