Basit öğe kaydını göster

dc.contributor.authorKınıklı, Gülay
dc.contributor.otherTürkçapar, Nuran
dc.contributor.otherDizbay Sak, Serpil
dc.contributor.otherDuman, Murat
dc.date.accessioned2020-03-23T08:34:34Z
dc.date.available2020-03-23T08:34:34Z
dc.date.issued2005
dc.identifier.urihttps://doi.org/10.1007/s00296-005-0606-xtr_TR
dc.identifier.urihttp://hdl.handle.net/20.500.12575/70750
dc.description.abstractBackground: Allergen-specific immunotherapy (SIT) is a well-documented treatment for allergic rhinitis, asthma, and allergy to bee venoms. Side-effects of SIT in long-term have not been well documented yet. Herein, we report a case of Sjögren's syndrome following SIT. Case: The patient, a 25-year-old Caucasian woman, was started on subcutaneous grass-pollen immunotherapy. The patient's autoantibodies before the SIT screening tests were negative. We determined that anti-extractable nuclear antigen (ENA) was positive (ENA = 98.4, normal range 0-25 U) on routine screening tests at 44 weeks of her treatment, and then SIT was discontinued. The patient complained of burning and itching in her eyes for 6 months. Schirmer's and salivary flow tests were positive. Although antinuclear antigen and rheumatoid factor were negative, anti-SS-A/Ro was positive. Viral hepatitis markers were negative. Minor salivary-gland biopsy was performed, which showed grade 4 sialoadenitis. The HLA type of the patient was B55 (B22), Bw6, Cw1 for class I and DR11, DR52, DQ7 (DQ3) for class II. After the immunotherapy had been stopped, there were no changes in the symptoms and laboratory findings of the patient during the 1st year of follow-up. Conclusion: This is the first case to be reported of Sjögren's syndrome following SIT. Patients undergoing SIT must be carefully followed up for the development of autoimmunity and an autoimmune disease. © Springer-Verlag 2005.tr_TR
dc.language.isoentr_TR
dc.relation.isversionof10.1007/s00296-005-0606-xtr_TR
dc.subjectImmunotherapytr_TR
dc.subjectImmunotherapy-induced autoimmune diseasetr_TR
dc.subjectImmunotherapy-inducedtr_TR
dc.subjectSjögren's syndrometr_TR
dc.subjectSjögren's syndrometr_TR
dc.titleSpecific immunotherapy-induced Sjögren's syndrometr_TR
dc.typeArticletr_TR
dc.relation.journalRheumatology Internationaltr_TR
dc.contributor.departmentTıp Fakültesitr_TR
dc.identifier.volume26tr_TR
dc.identifier.issue2tr_TR
dc.identifier.startpage182tr_TR
dc.identifier.endpage184tr_TR
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıtr_TR


Bu öğenin dosyaları:

Bu öğe aşağıdaki koleksiyon(lar)da görünmektedir.

Basit öğe kaydını göster